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Yumiko Kubota

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Articles 64
Citations 831
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Tatsukawa K, Sakamoto R, Kawasoe Y, Kubota Y, Tsurimoto T, Takahashi T, et al.
Nucleic Acids Res . 2024 Feb; 52(6):3146-3163. PMID: 38349040
Sensing and processing of DNA double-strand breaks (DSBs) are vital to genome stability. DSBs are primarily detected by the ATM checkpoint pathway, where the Mre11-Rad50-Nbs1 (MRN) complex serves as the...
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Hashizume H, Sawa R, Kubota Y, Adachi S, Harada S, Igarashi M
J Antibiot (Tokyo) . 2024 Jan; 77(4):238-244. PMID: 38267574
Tripropeptin C, a non-ribosomal cyclic lipopeptide containing three proline residues, exhibits excellent efficacy in the mouse-methicillin-resistant Staphylococcus aureus septicemia model. Since tripropeptins contain L-prolyl-D-proline and, as a result, are known...
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Maekawa K, Sawa R, Matsui M, Konda T, Kubota Y, Matsuo A, et al.
J AOAC Int . 2023 Dec; 107(2):234-241. PMID: 38070143
Background: Through the recent development of analytical technology, antibiotics quantification in the Japanese Pharmacopoeia (JP) has changed from traditional microbiological assays to physicochemical methods with high specificity and precision. However,...
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Yamasaki M, Sawa R, Muramatsu H, Yamamoto Y, Umekita M, Kubota Y, et al.
J Antibiot (Tokyo) . 2023 Nov; 77(2):85-92. PMID: 38008738
Hepatitis B virus (HBV) causes chronic hepatitis in humans, and current antiviral therapies rarely treat viral infections. To improve the treatment efficacy, novel therapeutic agents, especially those with different mechanisms...
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Ishizaki Y, Umekita M, Arisaka R, Hatano M, Kimura T, Kubota Y, et al.
J Antibiot (Tokyo) . 2023 Sep; 76(12):691-698. PMID: 37758819
Pseudomonas aeruginosa is one of the most concerning pathogenic bacteria. We screened antibiotics using a highly drug-sensitive P. aeruginosa strain and an oligotrophic medium, and successfully isolated novel antibiotics, namely...
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Mizuno Y, Ito T, Ueda K, Tashiro A, Kubota Y, Yamashita A, et al.
Clin J Gastroenterol . 2022 Oct; 15(6):1193-1197. PMID: 36264476
A 66-year-old Japanese woman had been diagnosed with a neuroendocrine tumor of the pancreatic head (G2) 3 years previously and undergone pancreaticoduodenectomy. Nine months postoperatively, recurrence with multiple liver metastases...
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Wada S, Arimura H, Nagayoshi M, Sawa R, Kubota Y, Matoba K, et al.
Adv Biol (Weinh) . 2022 Mar; 6(6):e2101309. PMID: 35297567
Nonreducing disaccharide trehalose is used as a stabilizer and humectant in various products and is a potential medicinal drug, showing curative effects on the animal models of various diseases. However,...
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Ito A, Suzuki K, Matsunaga K, Yagami A, Ito T, Tamagawa-Mineoka R, et al.
Contact Dermatitis . 2021 Dec; 86(3):189-195. PMID: 34921568
Background: The Japanese baseline series (JBS), established in 1994, was updated in 2008 and 2015. The JBS 2015 is a modification of the thin-layer rapid-use epicutaneous (TRUE) test (SmartPractice Denmark,...
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Kohda Y, Sakamoto S, Umekita M, Kimura T, Kubota Y, Arisaka R, et al.
J Antibiot (Tokyo) . 2021 Dec; 75(2):77-85. PMID: 34873311
New three macrocyclic diolides, named bispolides C-E (1-3), were isolated from a fermentation broth of the actinomycete strain MG372-hF19, which produces an indole glycoside and leptomycins as we reported previously....