Yoshiaki Terauchi
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Explore the profile of Yoshiaki Terauchi including associated specialties, affiliations and a list of published articles.
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11
Citations
87
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Recent Articles
1.
Teramoto T, Fukao T, Tomita Y, Terauchi Y, Hosoi K, Matsui E, et al.
Allergol Int
. 2006 Nov;
55(3):317-20.
PMID: 17075274
Background: Hydrofluoroalkane-134a (HFA) has been shown to be a safe replacement for chlorofluorocarbons (CFCs) as a pharmaceutical propellant, with the advantage that it has no ozone-depleting potential. This is the...
2.
Nomura N, Matsumoto S, Nishimura Y, Terauchi Y, Fujii T
Arzneimittelforschung
. 2006 Apr;
56(3):258-66.
PMID: 16618019
Although breath test using 13C-labeled urea (CAS 57-13-6, UBT) is becoming popular for the diagnosis of Helicobacter pylori (H. pylori) infection, disposition of exogenously given urea is not fully understood....
3.
Ochi T, Sakamoto M, Minamida A, Suzuki K, Ueda T, Une T, et al.
Bioorg Med Chem Lett
. 2005 Feb;
15(4):1055-9.
PMID: 15686911
Two major metabolites in humans of blonanserin, 2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta-[b]pyridine (code name AD-5423), were synthesized. The first, 7-hydroxylated AD-5423, was synthesized through a four-step process starting from 4-fluorobenzoylacetonitrile (1), and the second,...
4.
Iwasaki M, Yoshimura Y, Asahi S, Saito K, Sakai S, Morita S, et al.
Drug Metab Pharmacokinet
. 2005 Feb;
19(6):444-52.
PMID: 15681899
As a part of the studies conducted by the Pharma SNPs Consortium (PSC), the enzyme activities of CYP1A2, CYP2A6 and CYP2B6 variants with altered amino acids as a result of...
5.
Toide K, Umeda S, Yamazaki H, Takahashi Y, Terauchi Y, Fujii T, et al.
Drug Metab Pharmacokinet
. 2004 Dec;
17(2):164-6.
PMID: 15618667
A novel single nucleotide polymorphism (SNP) was found in exon 6 of the UDP-glucuronosyltransferase (UGT) 2B15 gene from healthy Japanese populations. The SNP was as follows: SNP, 020228Toide001; GENE NAME,...
6.
Mise M, Hashizume T, Matsumoto S, Terauchi Y, Fujii T
Pharmacogenetics
. 2004 Nov;
14(11):769-73.
PMID: 15564884
Objectives: Recently, we reported that AC-3933, a novel cognitive enhancer, is polymorphically hydroxylated in beagle dogs and that dogs could be phenotyped as extensive metabolizers (EM) or poor metabolizers (PM)....
7.
Toide K, Terauchi Y, Fujii T, Yamazaki H, Kamataki T
Biochem Pharmacol
. 2004 Mar;
67(7):1269-78.
PMID: 15013842
N-Glucosidation is known as a major metabolic reaction for barbiturates in humans. However, the enzyme(s) involved in this N-glucosidation has not been clarified yet. Thus, to clarify the enzyme(s) involved...
8.
Mise M, Yadera S, Matsuda M, Hashizume T, Matsumoto S, Terauchi Y, et al.
Drug Metab Dispos
. 2004 Jan;
32(2):240-5.
PMID: 14744947
5-(3-methoxyphenyl)-3-(5-methyl-1,2,4-oxadiazol-3-yl)-2-oxo-1,2-dihydro-1,6-naphthyridine (AC-3933) is a novel cognitive enhancer with central benzodiazepine receptor partial inverse agonistic activity. AC-3933 is predominantly metabolized to hydroxylated metabolite [SX-5745; 3-(5-hydroxymethyl-1,2,4-oxadiazol-3-yl)-5-(3-methoxyphenyl)-2-oxo-1,2-dihydro-1,6-naphthyridine] in dog. Initially, we found that...
9.
Takagaki T, Matsuda M, Mizuki Y, Terauchi Y
J Chromatogr B Analyt Technol Biomed Life Sci
. 2002 Jul;
776(2):169-76.
PMID: 12137998
A convenient liquid chromatographic-single quadrupole mass spectrometric (LC-MS) method was developed and validated for the determination of chlorpheniramine maleate (INN name: chlorphenamine) in human plasma. The method had advantages of...
10.
Toide K, Takahashi Y, Yamazaki H, Terauchi Y, Fujii T, Parkinson A, et al.
Drug Metab Dispos
. 2002 May;
30(6):613-5.
PMID: 12019184
UDP-glucuronosyltransferase (UGT) 2B7 is one of the most important UGT isozymes expressed in human livers. This enzyme is reported to show more than 10-fold interindividual differences in its enzyme activities....