Hiroshi Yamazaki
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Explore the profile of Hiroshi Yamazaki including associated specialties, affiliations and a list of published articles.
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641
Citations
3579
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Recent Articles
1.
Uno Y, Ushirozako G, Murayama N, Yamazaki H
Biochem Pharmacol
. 2025 Mar;
235:116846.
PMID: 40032162
Essential drug-metabolizing enzymes, such as the cytochromes P450 (P450s or CYPs), have been analyzed in dogs, which are frequently used during drug development. Dog CYP3A12, CYP3A26, CYP3A98, and CYP3A99 have...
2.
Kojima A, Nadai M, Yamazaki H, Katoh M
Drug Metab Pharmacokinet
. 2025 Feb;
61:101052.
PMID: 39923279
Arachidonic acid is metabolized to biologically active (±)14(15)-epoxy-5Z,8Z,11Z-eicosatrienoic acid (14,15-EET), and suppression of this step is believed to be a drug developmental target in cancer treatment. Although the key 14,15-epoxidation...
3.
Morita S, Inoue A, Kunihiro Y, Ono T, Endo S, Yamamoto T, et al.
J Comput Assist Tomogr
. 2025 Jan;
PMID: 39761497
Objective: Radiographic findings to identify central venous catheter misplacement in the arteries, which can cause lethal complications, have not been fully evaluated, and its training is difficult because it is...
4.
Ishida T, Kuroda Y, Matsue K, Komeno T, Ishiguro T, Ishikawa J, et al.
Int J Hematol
. 2024 Nov;
121(2):222-231.
PMID: 39607603
We characterized the safety and efficacy of the bispecific antibody teclistamab in Japanese patients with relapsed/refractory multiple myeloma (RRMM). Patients were pretreated with a proteasome inhibitor (PI), immunomodulatory drug (IMiD),...
5.
Koinuma K, Noto K, Morita T, Uekusa Y, Kikuchi H, Shimoji M, et al.
J Pharm Sci
. 2024 Oct;
114(2):849-856.
PMID: 39481475
Some citrus fruits are known to cause clinically significant drug interactions by inhibiting intestinal cytochrome P450 (CYP) enzymes. This in vitro study aimed to investigate the kinetics of the inhibition...
6.
Adachi K, Sasaki T, Arai A, Shimizu M, Yamazaki H
J Toxicol Sci
. 2024 Oct;
49(10):459-466.
PMID: 39358235
The octanol/water partition coefficient, P (logP), is a hydrophobicity index and is one of the determining factors of the pharmacokinetics of chemical compounds. LogP values obtained from in silico software,...
7.
Miyaoka S, Yamazaki H, Hayashi M, Isobe F, Abe Y, Sakurai T
JBJS Case Connect
. 2024 Sep;
14(3.
PMID: 39303048
Case: A 40-year-old man sustained a traumatic elbow disarticulation without any fracture, accompanied by severe damage of the biceps and brachialis. After replantation, passive elbow motion was used with a...
8.
Suzuki K, Yamada H, Yamazaki H, Honda G, Sakai S
Jpn J Radiol
. 2024 Aug;
43(1):51-55.
PMID: 39162781
Purpose: A large-scale language model is expected to have been trained with a large volume of data including cancer treatment protocols. The current study aimed to investigate the use of...
9.
Adachi K, Murata M, Inada A, Morimoto T, Shimizu M, Beppu S, et al.
Acute Med Surg
. 2024 Aug;
11(1):e985.
PMID: 39135990
Aim: The overdose of caffeine, a cytochrome P450 1A2 probe, in young women has become a problem. The aim of this study was to evaluate possible drug interactions between intentionally...
10.
Kojima A, Nadai M, Murayama N, Yamazaki H, Katoh M
Xenobiotica
. 2024 Aug;
54(9):642-647.
PMID: 39105612
Cytochrome P450 (CYP) 2J2 is responsible for the epoxidation of arachidonic acid, producing epoxyeicosatrienoic acids (EETs) that are known to enhance tumorigenesis. CYP2J2 is prominently expressed in the heart and...