Takanori Hashizume
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Explore the profile of Takanori Hashizume including associated specialties, affiliations and a list of published articles.
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20
Citations
376
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Recent Articles
1.
Terada T, Bunai T, Hashizume T, Matsudaira T, Yokokura M, Takashima H, et al.
Sci Rep
. 2024 Feb;
14(1):4708.
PMID: 38409373
The progression of neuroinflammation after anti-parkinsonian therapy on the Parkinson's disease (PD) brain and in vivo evidence of the therapy purporting neuroprotection remain unclear. To elucidate this, we examined changes...
2.
Oki M, Kaneko S, Morise S, Takenouchi N, Hashizume T, Tsuge A, et al.
Neurosci Res
. 2017 Jun;
122:45-50.
PMID: 28577977
To investigate the difference in results according to the mode of levodopa administration and the effect of zonisamide (ZNS), we analyzed the mRNA expression of dopaminergic and non-dopaminergic receptors in...
3.
Terada T, Yokokura M, Yoshikawa E, Futatsubashi M, Kono S, Konishi T, et al.
Ann Nucl Med
. 2016 Jun;
30(8):579-87.
PMID: 27299437
Background: The neuroinflammatory glial response contributes to the degenerative process in Parkinson's disease (PD). However, the pattern of microglial progression remains unclear. Methods: We evaluated microglial activation in early stage...
4.
Zonisamide suppresses endoplasmic reticulum stress-induced neuronal cell damage in vitro and in vivo
Tsujii S, Ishisaka M, Shimazawa M, Hashizume T, Hara H
Eur J Pharmacol
. 2014 Sep;
746:301-7.
PMID: 25261037
Zonisamide has been reported to have protective effects on epilepsy and Parkinson׳s disease and to work via various mechanisms of action, such as inhibition of monoamine oxidase-B and enhancement of...
5.
Uehara S, Murayama N, Nakanishi Y, Nakamura C, Hashizume T, Zeldin D, et al.
Xenobiotica
. 2014 Aug;
45(2):124-30.
PMID: 25138712
1. An increasing number of studies have indicated the roles of CYP4 proteins in drug metabolism; however, CYP4 expression has not been measured in cynomolgus monkeys, an important animal species...
6.
Wang Z, Wong T, Hashizume T, Dickmann L, Scian M, Koszewski N, et al.
Endocrinology
. 2014 Mar;
155(6):2052-63.
PMID: 24641623
25-Hydroxyvitamin D3 (25OHD3) is used as a clinical biomarker for assessment of vitamin D status. Blood levels of 25OHD3 represent a balance between its formation rate and clearance by several...
7.
Uehara S, Murayama N, Nakanishi Y, Nakamura C, Hashizume T, Zeldin D, et al.
Xenobiotica
. 2014 Mar;
44(9):769-74.
PMID: 24593267
The expression of small intestinal cytochromes P450 (P450s) has not been systematically measured in cynomolgus monkeys, which are widely used in preclinical drug studies to predict pharmacokinetics and toxicity in...
8.
Inoue T, Osada K, Tagawa M, Ogawa Y, Haga T, Sogame Y, et al.
Prog Neuropsychopharmacol Biol Psychiatry
. 2012 Jun;
39(1):156-62.
PMID: 22691713
Although blonanserin, a novel atypical antipsychotic agent with dopamine D(2)/serotonin 5-HT(2A) antagonistic properties, displays good brain distribution, the mechanism of this distribution has not been clarified. P-glycoprotein [(P-gp) or multidrug...
9.
Wang Z, Lin Y, Zheng X, Senn T, Hashizume T, Scian M, et al.
Mol Pharmacol
. 2011 Dec;
81(4):498-509.
PMID: 22205755
Vitamin D(3) is critical for the regulation of calcium and phosphate homeostasis. In some individuals, mineral homeostasis can be disrupted by long-term therapy with certain antiepileptic drugs and the antimicrobial...
10.
Usui T, Hashizume T, Katsumata T, Yokoi T, Komuro S
Drug Metab Dispos
. 2011 Apr;
39(7):1303-10.
PMID: 21511944
The double null mutation of glutathione transferase, GSTM1 and GSTT1, is reported to influence troglitazone-associated abnormal increases of alanine aminotransferase and aspartate aminotransferase. However, no nonclinical data with a bearing...