Yohei Katsuyama
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Explore the profile of Yohei Katsuyama including associated specialties, affiliations and a list of published articles.
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70
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723
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Recent Articles
1.
Kawai S, Moriga K, Nirdnoy W, Hara R, Ogawa J, Katsuyama Y, et al.
Chemistry
. 2025 Feb;
:e202404790.
PMID: 39960436
Enzymes that catalyze regioselective and stereoselective hydroxylation of amino acids are useful tools for the synthesis of pharmaceuticals. AzpK is an unprecedented lysine 5-hydroxylase that is involved in alazopeptin biosynthesis,...
2.
Zdouc M, Blin K, Louwen N, Navarro J, Loureiro C, Bader C, et al.
Nucleic Acids Res
. 2024 Dec;
53(D1):D678-D690.
PMID: 39657789
Specialized or secondary metabolites are small molecules of biological origin, often showing potent biological activities with applications in agriculture, engineering and medicine. Usually, the biosynthesis of these natural products is...
3.
Kato H, Tanemura H, Kimura T, Katsuyama Y, Tezuka T, Ohnishi Y
Commun Biol
. 2024 Oct;
7(1):1405.
PMID: 39472762
Zoospores of the filamentous actinomycete Actinoplanes missouriensis swim vigorously using flagella and stop swimming to initiate germination in response to nutrient exposure. However, the molecular mechanisms underlying swimming cessation remain...
4.
Kawai S, Ning J, Katsuyama Y, Ohnishi Y
Chembiochem
. 2024 Oct;
26(1):e202400687.
PMID: 39420540
The diazo group is an important functional group in organic synthesis because it confers high reactivity to the compounds and has been applied in various chemical reactions, such as the...
5.
Sakata S, Li J, Yasuno Y, Shinada T, Shin-Ya K, Katsuyama Y, et al.
Chemistry
. 2024 Mar;
30(28):e202400271.
PMID: 38456538
Cirratiomycin, a heptapeptide with antibacterial activity, was isolated and characterized in 1981; however, its biosynthetic pathway has not been elucidated. It contains several interesting nonproteinogenic amino acids, such as (2S,3S)-2,3-diaminobutyric...
6.
Kawai S, Yamada A, Katsuyama Y, Ohnishi Y
Beilstein J Org Chem
. 2024 Jan;
20:1-11.
PMID: 38213839
Recently, we identified the biosynthetic gene cluster of avenalumic acid ( cluster) and revealed its entire biosynthetic pathway, resulting in the discovery of a diazotization-dependent deamination pathway. Genome database analysis...
7.
Shikai Y, Kawai S, Katsuyama Y, Ohnishi Y
Chem Sci
. 2023 Aug;
14(33):8766-8776.
PMID: 37621439
Azaserine, a natural product containing a diazo group, exhibits anticancer activity. In this study, we investigated the biosynthetic pathway to azaserine. The putative azaserine biosynthetic gene () cluster, which contains...
8.
Kawai S, Yamada A, Du D, Sugai Y, Katsuyama Y, Ohnishi Y
ACS Chem Biol
. 2023 Jul;
18(8):1821-1828.
PMID: 37498311
Natural products containing nitrogen-nitrogen (N-N) bonds have attracted much attention because of their bioactivities and chemical features. Several recent studies have revealed the nitrous acid-dependent N-N bond-forming machinery. However, the...
9.
Ogawa Y, Saito Y, Yamaguchi H, Katsuyama Y, Ohnishi Y
ACS Synth Biol
. 2023 Feb;
12(2):572-582.
PMID: 36734676
Enzyme engineering using machine learning has been developed in recent years. However, to obtain a large amount of data on enzyme activities for training data, it is necessary to develop...
10.
Katsuyama Y, Miyanaga A
Curr Opin Chem Biol
. 2022 Oct;
71:102223.
PMID: 36265331
Polyketides and nonribosomal peptides are an important class of natural products with useful bioactivities. These compounds are similarly biosynthesized using enzymes with modular structures despite having different physicochemical properties. These...