Miho Izumikawa
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Explore the profile of Miho Izumikawa including associated specialties, affiliations and a list of published articles.
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81
Citations
899
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Recent Articles
1.
Nishimura T, Kudo K, Izumikawa M, Kozone I, Hashimoto J, Kagaya N, et al.
Chem Pharm Bull (Tokyo)
. 2024 May;
72(5):475-479.
PMID: 38749722
Heterologous expression of natural compound biosynthetic gene clusters (BGCs) is a robust approach for not only revealing the biosynthetic mechanisms leading to the compounds, but also for discovering new products...
2.
Kudo K, Nishimura T, Izumikawa M, Kozone I, Hashimoto J, Fujie M, et al.
J Antibiot (Tokyo)
. 2024 Mar;
77(5):288-298.
PMID: 38438499
The biosynthetic gene clusters (BGCs) for the macrocyclic lactone-based polyketide compounds are extremely large-sized because the polyketide synthases that generate the polyketide chains of the basic backbone are of very...
3.
Kawahara T, Itoh M, Izumikawa M, Kagaya N, Sakata N, Tsuchida T, et al.
Biosci Biotechnol Biochem
. 2020 Apr;
84(8):1570-1575.
PMID: 32338185
Chemical screening of culture medium from the soil fungus sp. resulted in the isolation of the three new phenylspirodrimanes MBJ-0030 (), MBJ-0031 () and MBJ-0032 (). Their structures were determined...
4.
Ohsawa K, Yoshida M, Izumikawa M, Takagi M, Shin-Ya K, Goshima N, et al.
Bioorg Med Chem
. 2018 Nov;
26(23-24):6023-6034.
PMID: 30455074
The synthesis and biological evaluation of thielocin B1 analogues have been demonstrated. Fourteen analogues modified in the central core and terminal carboxylic acid moiety were concisely synthesized by simple esterification...
5.
Tsutsumi H, Katsuyama Y, Izumikawa M, Takagi M, Fujie M, Satoh N, et al.
J Am Chem Soc
. 2018 May;
140(21):6631-6639.
PMID: 29716187
Benzastatins have unique structures probably derived from geranylated p-aminobenzoic acids. The indoline and tetrahydroquinoline scaffolds are presumably formed by cyclization of the geranyl moiety, but the cyclization mechanism was unknown....
6.
Kawahara T, Izumikawa M, Kozone I, Hashimoto J, Kagaya N, Koiwai H, et al.
J Nat Prod
. 2018 Jan;
81(2):264-269.
PMID: 29381067
During genome mining for thioviridamide-like biosynthetic gene clusters that could produce polythioamide RiPP (ribosomally synthesized and post-translationally modified peptides), we discovered a novel cryptic biosynthetic gene cluster. During efforts to...
7.
Amagai K, Ikeda H, Hashimoto J, Kozone I, Izumikawa M, Kudo F, et al.
Sci Rep
. 2017 Jun;
7(1):3382.
PMID: 28611443
Telomestatin, a strong telomerase inhibitor with G-quadruplex stabilizing activity, is a potential therapeutic agent for treating cancers. Difficulties in isolating telomestatin from microbial cultures and in chemical synthesis are bottlenecks...
8.
Tsukamoto H, Hanada S, Kumasaka K, Kagaya N, Izumikawa M, Shin-Ya K, et al.
Org Lett
. 2016 Sep;
18(19):4848-4851.
PMID: 27648608
Two benzo analogues of cytotoxic spiromamakone A, comprising carbon atoms with the same oxidation state and unsaturation degree as those of the natural products, are synthesized and biologically evaluated. Substitution...
9.
Kawahara T, Itoh M, Izumikawa M, Sakata N, Tsuchida T, Shin-Ya K
J Antibiot (Tokyo)
. 2016 Sep;
70(2):226-229.
PMID: 27624401
No abstract available.
10.
Ye Y, Minami A, Igarashi Y, Izumikawa M, Umemura M, Nagano N, et al.
Angew Chem Int Ed Engl
. 2016 May;
55(28):8072-5.
PMID: 27166860
The biosynthetic machinery of the first fungal ribosomally synthesized and post-translationally modified peptide (RiPP) ustiloxin B was elucidated through a series of gene inactivation and heterologous expression studies. The results...