Yevgeny Daikhin
Overview
Explore the profile of Yevgeny Daikhin including associated specialties, affiliations and a list of published articles.
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33
Citations
1052
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Recent Articles
1.
Raju K, Doulias P, Evans P, Krizman E, Jackson J, Horyn O, et al.
Sci Signal
. 2015 Jul;
8(384):ra68.
PMID: 26152695
Nitric oxide (NO) is a signaling intermediate during glutamatergic neurotransmission in the central nervous system (CNS). NO signaling is in part accomplished through cysteine S-nitrosylation, a posttranslational modification by which...
2.
Shen T, Albenberg L, Bittinger K, Chehoud C, Chen Y, Judge C, et al.
J Clin Invest
. 2015 Jun;
125(7):2841-50.
PMID: 26098218
Increasing evidence indicates that the gut microbiota can be altered to ameliorate or prevent disease states, and engineering the gut microbiota to therapeutically modulate host metabolism is an emerging goal...
3.
Mew N, McCarter R, Daikhin Y, Lichter-Konecki U, Nissim I, Yudkoff M, et al.
J Pediatr
. 2014 Jun;
165(2):401-403.e3.
PMID: 24880889
Identical studies using stable isotopes were performed before and after a 3-day trial of oral N-carbamyl-l-glutamate (NCG) in 5 subjects with late-onset carbamyl phosphate synthetase deficiency. NCG augmented ureagenesis and...
4.
Nissim I, Horyn O, Daikhin Y, Chen P, Li C, Wehrli S, et al.
J Biol Chem
. 2014 Feb;
289(14):9710-29.
PMID: 24523404
Agmatine (AGM), a product of arginine decarboxylation, influences multiple physiologic and metabolic functions. However, the mechanism(s) of action, the impact on whole body gene expression and metabolic pathways, and the...
5.
Li C, Liu C, Nissim I, Chen J, Chen P, Doliba N, et al.
J Biol Chem
. 2012 Dec;
288(6):3938-51.
PMID: 23266825
Paracrine signaling between pancreatic islet β-cells and α-cells has been proposed to play a role in regulating glucagon responses to elevated glucose and hypoglycemia. To examine this possibility in human...
6.
Nissim I, Horyn O, Nissim I, Daikhin Y, Wehrli S, Yudkoff M, et al.
Biochem J
. 2012 Mar;
444(3):537-51.
PMID: 22448977
GKAs (glucokinase activators) are promising agents for the therapy of Type 2 diabetes, but little is known about their effects on hepatic intermediary metabolism. We monitored the fate of (13)C-labelled...
7.
Heibel S, Mew N, Caldovic L, Daikhin Y, Yudkoff M, Tuchman M
Hum Mutat
. 2011 Jun;
32(10):1153-60.
PMID: 21681857
N-acetylglutamate synthase (NAGS) catalyzes the conversion of glutamate and acetyl-CoA to NAG, the essential allosteric activator of carbamyl phosphate synthetase I, the first urea cycle enzyme in mammals. A 17-year-old...
8.
Nissim I, Horyn O, Nissim I, Daikhin Y, Caldovic L, Barcelona B, et al.
J Biol Chem
. 2011 May;
286(25):22055-68.
PMID: 21540182
We previously reported that isobutylmethylxanthine (IBMX), a derivative of oxypurine, inhibits citrulline synthesis by an as yet unknown mechanism. Here, we demonstrate that IBMX and other oxypurines containing a 2,6-dione...
9.
Mew N, McCarter R, Daikhin Y, Nissim I, Yudkoff M, Tuchman M
Pediatrics
. 2010 Jun;
126(1):e208-14.
PMID: 20566609
Objectives: The objective of this study was to determine whether N-carbamylglutamate (NCG) reduces plasma levels of ammonia and glutamine and increases the rate of ureagenesis in patients with propionic acidemia...
10.
Yudkoff M, Mew N, Daikhin Y, Horyn O, Nissim I, Nissim I, et al.
Mol Genet Metab
. 2010 Mar;
100 Suppl 1:S37-41.
PMID: 20338795
Stable isotopes have been an invaluable adjunct to biomedical research for more than 70years. Indeed, the isotopic approach has revolutionized our understanding of metabolism, revealing it to be an intensely...