Adam Lazarow
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Explore the profile of Adam Lazarow including associated specialties, affiliations and a list of published articles.
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9
Citations
237
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Recent Articles
1.
Li C, Matter A, Kelly A, Petty T, Najafi H, MacMullen C, et al.
J Biol Chem
. 2006 Apr;
281(22):15064-72.
PMID: 16574664
Glutamate dehydrogenase (GDH) plays an important role in insulin secretion as evidenced in children by gain of function mutations of this enzyme that cause a hyperinsulinism-hyperammonemia syndrome (GDH-HI) and sensitize...
2.
Yudkoff M, Daikhin Y, Nissim I, Horyn O, Luhovyy B, Lazarow A, et al.
Neurochem Int
. 2006 Mar;
48(6-7):650-6.
PMID: 16510212
The ketogenic diet is an effective treatment for seizures, but the mechanism of action is unknown. It is uncertain whether the anti-epileptic effect presupposes ketosis, or whether the restriction of...
3.
Yudkoff M, Daikhin Y, Nissim I, Horyn O, Luhovyy B, Luhovyy B, et al.
J Nutr
. 2005 Jun;
135(6 Suppl):1531S-8S.
PMID: 15930465
Glutamic acid is an important excitatory neurotransmitter of the brain. Two key goals of brain amino acid handling are to maintain a very low intrasynaptic concentration of glutamic acid and...
4.
Yudkoff M, Daikhin Y, Nissim I, Horyn O, Lazarow A, Luhovyy B, et al.
Neurochem Int
. 2005 May;
47(1-2):119-28.
PMID: 15888376
Our objective was to study brain amino acid metabolism in response to ketosis. The underlying hypothesis is that ketosis is associated with a fundamental change of brain amino acid handling...
5.
Horyn O, Luhovyy B, Lazarow A, Daikhin Y, Nissim I, Yudkoff M, et al.
Biochem J
. 2005 Jan;
388(Pt 2):419-25.
PMID: 15656789
An important but unresolved question is whether mammalian mitochondria metabolize arginine to agmatine by the ADC (arginine decarboxylase) reaction. 15N-labelled arginine was used as a precursor to address this question...
6.
Yudkoff M, Daikhin Y, Nissim I, Lazarow A, Nissim I
Prostaglandins Leukot Essent Fatty Acids
. 2004 Feb;
70(3):277-85.
PMID: 14769486
We do not know the mode of action of the ketogenic diet in controlling epilepsy. One possibility is that the diet alters brain handling of glutamate, the major excitatory neurotransmitter...
7.
Nissim I, Horyn O, Luhovyy B, Lazarow A, Daikhin Y, Nissim I, et al.
Biochem J
. 2003 Aug;
376(Pt 1):179-88.
PMID: 12935293
The present study was designed to determine: (i) the role of the reductive amination of alpha-ketoglutarate via the glutamate dehydrogenase reaction in furnishing mitochondrial glutamate and its transamination into aspartate;...
8.
Yudkoff M, Daikhin Y, Nissim I, Horyn O, Lazarow A, Nissim I
Epilepsy Res
. 2003 Feb;
53(1-2):151-62.
PMID: 12576176
We studied the effects of pentylenetetrazole (PTZ) on brain amino acid metabolism in mice. Administration of this convulsant did not change forebrain concentrations of amino acids, but when treated animals...
9.
Nissim I, Horyn O, Daikhin Y, Nissim I, Lazarow A, Yudkoff M
Am J Physiol Endocrinol Metab
. 2002 Oct;
283(6):E1123-34.
PMID: 12388162
Administration of arginine or a high-protein diet increases the hepatic content of N-acetylglutamate (NAG) and the synthesis of urea. However, the underlying mechanism is unknown. We have explored the hypothesis...