Yang E Li
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Explore the profile of Yang E Li including associated specialties, affiliations and a list of published articles.
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10
Citations
350
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Recent Articles
1.
Yu M, Zemke N, Chen Z, Juric I, Hu R, Raviram R, et al.
Nat Struct Mol Biol
. 2024 Dec;
PMID: 39681766
While a rich set of putative cis-regulatory sequences involved in mouse fetal development have been annotated recently on the basis of chromatin accessibility and histone modification patterns, delineating their role...
2.
Liu J, Cao S, Imbach K, Gritsenko M, Lih T, Kyle J, et al.
Cancer Cell
. 2024 Jul;
42(7):1217-1238.e19.
PMID: 38981438
Although genomic anomalies in glioblastoma (GBM) have been well studied for over a decade, its 5-year survival rate remains lower than 5%. We seek to expand the molecular landscape of...
3.
Li Y, Norris D, Xiao F, Pandzic E, Whan R, Fok S, et al.
J Cell Biol
. 2024 Mar;
223(6).
PMID: 38530252
The integrity of the plasma membrane is critical to cell function and survival. Cells have developed multiple mechanisms to repair damaged plasma membranes. A key process during plasma membrane repair...
4.
Tian W, Zhou J, Bartlett A, Zeng Q, Liu H, Castanon R, et al.
Science
. 2023 Oct;
382(6667):eadf5357.
PMID: 37824674
Delineating the gene-regulatory programs underlying complex cell types is fundamental for understanding brain function in health and disease. Here, we comprehensively examined human brain cell epigenomes by probing DNA methylation...
5.
Zhang K, Hocker J, Miller M, Hou X, Chiou J, Poirion O, et al.
Cell
. 2021 Nov;
184(24):5985-6001.e19.
PMID: 34774128
Current catalogs of regulatory sequences in the human genome are still incomplete and lack cell type resolution. To profile the activity of gene regulatory elements in diverse cell types and...
6.
Tan C, Zhu S, Chen Z, Liu C, Li Y, Zhu M, et al.
PLoS Genet
. 2021 Sep;
17(9):e1009785.
PMID: 34506481
Dysregulation of cardiac transcription programs has been identified in patients and families with heart failure, as well as those with morphological and functional forms of congenital heart defects. Mediator is...
7.
Zhang T, Li Y, Yuan Y, Du X, Wang Y, Dong X, et al.
Autophagy
. 2021 Jun;
17(8):2048-2050.
PMID: 34074213
TMEM41B and VMP1, two endoplasmic reticulum (ER)-resident transmembrane proteins, play important roles in regulating the formation of lipid droplets (LDs), autophagy initiation, and viral infection. However, the biochemical functions of...
8.
Hocker J, Poirion O, Zhu F, Buchanan J, Zhang K, Chiou J, et al.
Sci Adv
. 2021 May;
7(20).
PMID: 33990324
Misregulated gene expression in human hearts can result in cardiovascular diseases that are leading causes of mortality worldwide. However, the limited information on the genomic location of candidate cis-regulatory elements...
9.
Yan J, Qiu Y, Ribeiro Dos Santos A, Yin Y, Li Y, Vinckier N, et al.
Nature
. 2021 Jan;
591(7848):147-151.
PMID: 33505025
Many sequence variants have been linked to complex human traits and diseases, but deciphering their biological functions remains challenging, as most of them reside in noncoding DNA. Here we have...
10.
Xu Y, Mak H, Lukmantara I, Li Y, Hoehn K, Huang X, et al.
J Biol Chem
. 2019 Sep;
294(45):16740-16755.
PMID: 31548309
Lipid droplets (LDs) are evolutionarily conserved organelles that play critical roles in mammalian lipid storage and metabolism. However, the molecular mechanisms governing the biogenesis and growth of LDs remain poorly...