James D Hocker
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Explore the profile of James D Hocker including associated specialties, affiliations and a list of published articles.
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12
Citations
740
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Recent Articles
1.
Whitehead A, Atcha H, Hocker J, Ren B, Engler A
J Cell Sci
. 2023 Nov;
136(23).
PMID: 37994565
Matrix remodeling outcomes largely dictate patient survival post myocardial infarction. Moreover, human-restricted noncoding regulatory elements have been shown to worsen fibrosis, but their mechanism of action remains elusive. Here, we...
2.
Quon S, Yu B, Russ B, Tsyganov K, Nguyen H, Toma C, et al.
Immunity
. 2023 Apr;
56(5):959-978.e10.
PMID: 37040762
Although the importance of genome organization for transcriptional regulation of cell-fate decisions and function is clear, the changes in chromatin architecture and how these impact effector and memory CD8 T ...
3.
Kirkland N, Skalak S, Whitehead A, Hocker J, Beri P, Vogler G, et al.
Nat Aging
. 2023 Feb;
3(1):17-33.
PMID: 36845078
As we age, structural changes contribute to progressive decline in organ function, which in the heart act through poorly characterized mechanisms. Taking advantage of the short lifespan and conserved cardiac...
4.
Whitehead A, Hocker J, Ren B, Engler A
J Mol Cell Cardiol
. 2021 Nov;
164:58-68.
PMID: 34826415
Since the initial isolation of human embryonic stem cells and subsequent discovery of reprogramming methods for somatic cells, thousands of protocols have been developed to create each of the hundreds...
5.
Zhang K, Hocker J, Miller M, Hou X, Chiou J, Poirion O, et al.
Cell
. 2021 Nov;
184(24):5985-6001.e19.
PMID: 34774128
Current catalogs of regulatory sequences in the human genome are still incomplete and lack cell type resolution. To profile the activity of gene regulatory elements in diverse cell types and...
6.
Hocker J, Poirion O, Zhu F, Buchanan J, Zhang K, Chiou J, et al.
Sci Adv
. 2021 May;
7(20).
PMID: 33990324
Misregulated gene expression in human hearts can result in cardiovascular diseases that are leading causes of mortality worldwide. However, the limited information on the genomic location of candidate cis-regulatory elements...
7.
Kubo N, Ishii H, Xiong X, Bianco S, Meitinger F, Hu R, et al.
Nat Struct Mol Biol
. 2021 Jan;
28(2):152-161.
PMID: 33398174
The CCCTC-binding factor (CTCF) works together with the cohesin complex to drive the formation of chromatin loops and topologically associating domains, but its role in gene regulation has not been...
8.
Ji Y, Fioravanti J, Zhu W, Wang H, Wu T, Hu J, et al.
Nat Commun
. 2019 May;
10(1):2157.
PMID: 31089138
T cell senescence and exhaustion are major barriers to successful cancer immunotherapy. Here we show that miR-155 increases CD8 T cell antitumor function by restraining T cell senescence and functional...
9.
Gautam S, Fioravanti J, Zhu W, Le Gall J, Brohawn P, Lacey N, et al.
Nat Immunol
. 2019 Feb;
20(3):337-349.
PMID: 30778251
Stem cells are maintained by transcriptional programs that promote self-renewal and repress differentiation. Here, we found that the transcription factor c-Myb was essential for generating and maintaining stem cells in...
10.
Sabatino M, Hu J, Sommariva M, Gautam S, Fellowes V, Hocker J, et al.
Blood
. 2016 May;
128(4):519-28.
PMID: 27226436
Long-lived, self-renewing, multipotent T memory stem cells (TSCM) can trigger profound and sustained tumor regression but their rareness poses a major hurdle to their clinical application. Presently, clinically compliant procedures...