Xin-Jie Chu
Overview
Explore the profile of Xin-Jie Chu including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
507
Followers
0
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Recent Articles
1.
Mo C, Xu X, Zhang P, Peng Y, Zhao X, Chen S, et al.
J Med Chem
. 2023 Jul;
66(14):9363-9375.
PMID: 37424079
The farnesoid X receptor (FXR) is a ligand-activated nuclear receptor. Activation of FXR significantly impacts the expressions of the pivotal genes involved in bile acid metabolism, inflammation, fibrosis, and homeostasis...
2.
Aldridge B, Barros-Aguirre D, Barry 3rd C, Bates R, Berthel S, Boshoff H, et al.
Nat Med
. 2021 Jul;
27(8):1333-1337.
PMID: 34226736
No abstract available.
3.
Lu G, Zhang X, Zheng W, Sun J, Hua L, Xu L, et al.
Antimicrob Agents Chemother
. 2021 Jun;
65(7):e0082021.
PMID: 34137638
No abstract available.
4.
Lu G, Zhang X, Zheng W, Sun J, Hua L, Xu L, et al.
Antimicrob Agents Chemother
. 2020 Oct;
65(1).
PMID: 33122171
Nucleotide analogs targeting viral RNA polymerase have been proved to be an effective strategy for antiviral treatment and are promising antiviral drugs to combat the current severe acute respiratory syndrome...
5.
Bakowski M, Shiroodi R, Liu R, Olejniczak J, Yang B, Gagaring K, et al.
Sci Transl Med
. 2019 May;
11(491).
PMID: 31068442
Parasitic filarial nematodes cause debilitating infections in people in resource-limited countries. A clinically validated approach to eliminating worms uses a 4- to 6-week course of doxycycline that targets , a...
6.
Bungard C, Williams P, Schulz J, Wiscount C, Holloway M, Loughran H, et al.
ACS Med Chem Lett
. 2017 Dec;
8(12):1292-1297.
PMID: 29259750
Using the HIV-1 protease binding mode of and as inspiration, a novel aspartate binding bicyclic piperazine sulfonamide core was designed and synthesized. The resulting HIV-1 protease inhibitor containing this core...
7.
Zhang Z, Ding Q, Liu J, Zhang J, Jiang N, Chu X, et al.
Bioorg Med Chem
. 2014 Jul;
22(15):4001-9.
PMID: 24997575
The field of small-molecule inhibitors of protein-protein interactions is rapidly advancing and the specific area of inhibitors of the p53/MDM2 interaction is a prime example. Several groups have published on...
8.
Zhang Z, Chu X, Liu J, Ding Q, Zhang J, Bartkovitz D, et al.
ACS Med Chem Lett
. 2014 Jun;
5(2):124-7.
PMID: 24900784
The development of small-molecule MDM2 inhibitors to restore dysfunctional p53 activities represents a novel approach for cancer treatment. In a previous communication, the efforts leading to the identification of a...
9.
Ding Q, Zhang Z, Liu J, Jiang N, Zhang J, Ross T, et al.
J Med Chem
. 2013 Jul;
56(14):5979-83.
PMID: 23808545
Restoration of p53 activity by inhibition of the p53-MDM2 interaction has been considered an attractive approach for cancer treatment. However, the hydrophobic protein-protein interaction surface represents a significant challenge for...
10.
Chen S, Bartkovitz D, Cai J, Chen Y, Chen Z, Chu X, et al.
Bioorg Med Chem Lett
. 2011 Dec;
22(2):1247-50.
PMID: 22172702
A series of pyrimidodiazepines was identified as potent Polo-like kinase 1 (PLK1) inhibitors. The synthesis and SAR are discussed. The lead compound 7 (RO3280) has potent inhibitory activity against PLK1,...