Xidong Feng
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Explore the profile of Xidong Feng including associated specialties, affiliations and a list of published articles.
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47
Citations
952
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Recent Articles
1.
Zhao H, Fang Y, Zhao Y, Tian Z, Zhang W, Feng X, et al.
Sensors (Basel)
. 2023 Mar;
23(6).
PMID: 36992056
The passive optical network (PON) is widely used in optical fiber communication thanks to its low cost and low resource consumption. However, the passiveness brings about a critical problem that...
2.
Ratnayake A, Flanagan M, Foley T, Hultgren S, Bellenger J, Montgomery J, et al.
Bioorg Med Chem
. 2021 May;
41:116205.
PMID: 34000509
The ability to predict chemical structure from DNA sequence has to date been a necessary cornerstone of DNA-encoded library technology. DNA-encoded libraries (DELs) are typically screened by immobilized affinity selection...
3.
Gopalsamy A, Aulabaugh A, Barakat A, Beaumont K, Cabral S, Canterbury D, et al.
J Med Chem
. 2020 Dec;
64(1):326-342.
PMID: 33356244
Sickle cell disease (SCD) is a genetic disorder caused by a single point mutation (β6 Glu → Val) on the β-chain of adult hemoglobin (HbA) that results in sickled hemoglobin...
4.
Schiemer J, Horst R, Meng Y, Montgomery J, Xu Y, Feng X, et al.
Nat Chem Biol
. 2020 Nov;
17(2):152-160.
PMID: 33199914
Heterobifunctional chimeric degraders are a class of ligands that recruit target proteins to E3 ubiquitin ligases to drive compound-dependent protein degradation. Advancing from initial chemical tools, protein degraders represent a...
5.
Fox N, Yu X, Feng X, Bailey H, Martelli A, Nabhan J, et al.
Nat Commun
. 2019 May;
10(1):2210.
PMID: 31101807
The core machinery for de novo biosynthesis of iron-sulfur clusters (ISC), located in the mitochondria matrix, is a five-protein complex containing the cysteine desulfurase NFS1 that is activated by frataxin...
6.
Majmudar J, Feng X, Fox N, Nabhan J, Towle T, Ma T, et al.
Medchemcomm
. 2019 Mar;
10(2):209-220.
PMID: 30881609
The mitochondrial acyl carrier protein (human ACPM, yeast Acp1) is an essential mitochondrial protein. Through binding of nascent acyl chains on the serine (S112)-bound 4'-phosphopantetheine (4'-PP) cofactor, ACPM is involved...
7.
Ratnayake A, Chang L, Tumey L, Loganzo F, Chemler J, Wagenaar M, et al.
Bioconjug Chem
. 2018 Dec;
30(1):200-209.
PMID: 30543418
A potent class of DNA-damaging agents, natural product bis-intercalator depsipeptides (NPBIDs), was evaluated as ultrapotent payloads for use in antibody-drug conjugates (ADCs). Detailed investigation of potency (both in cells and...
8.
Zorba A, Nguyen C, Xu Y, Starr J, Borzilleri K, Smith J, et al.
Proc Natl Acad Sci U S A
. 2018 Jul;
115(31):E7285-E7292.
PMID: 30012605
Proteolysis targeting chimeras (PROTACs) are heterobifunctional small molecules that simultaneously bind to a target protein and an E3 ligase, thereby leading to ubiquitination and subsequent degradation of the target. They...
9.
Rouet R, Thuma B, Roy M, Lintner N, Rubitski D, Finley J, et al.
J Am Chem Soc
. 2018 Apr;
140(21):6596-6603.
PMID: 29668265
CRISPR-Cas RNA-guided endonucleases hold great promise for disrupting or correcting genomic sequences through site-specific DNA cleavage and repair. However, the lack of methods for cell- and tissue-selective delivery currently limits...
10.
Fadeyi O, Hoth L, Choi C, Feng X, Gopalsamy A, Hett E, et al.
ACS Chem Biol
. 2017 Jul;
12(8):2015-2020.
PMID: 28718624
Irreversible enzyme inhibitors and covalent chemical biology probes often utilize the reaction of a protein cysteine residue with an appropriately positioned electrophile (e.g., acrylamide) on the ligand template. However, cysteine...