Xidong Feng
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Explore the profile of Xidong Feng including associated specialties, affiliations and a list of published articles.
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47
Citations
952
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Recent Articles
11.
Liu S, Desharnais J, Sahasrabudhe P, Jin P, Li W, Oates B, et al.
Sci Rep
. 2016 May;
6:26071.
PMID: 27184415
IL-17A is a pro-inflammatory cytokine that has been implicated in autoimmune and inflammatory diseases. Monoclonal antibodies inhibiting IL-17A signaling have demonstrated remarkable efficacy, but an oral therapy is still lacking....
12.
McCorvie T, Kopec J, Hyung S, Fitzpatrick F, Feng X, Termine D, et al.
J Biol Chem
. 2014 Oct;
289(52):36018-30.
PMID: 25336647
Cystathionine β-synthase (CBS) is a key enzyme in sulfur metabolism, and its inherited deficiency causes homocystinuria. Mammalian CBS is modulated by the binding of S-adenosyl-l-methionine (AdoMet) to its regulatory domain,...
13.
Hyung S, Feng X, Che Y, Stroh J, Shapiro M
Anal Bioanal Chem
. 2014 Jul;
406(24):5785-94.
PMID: 25064599
Cyclosporin is a family of neutral cyclic undecapeptides widely used for the prevention of organ transplant rejection and controlling viral infection. The equilibrium of conformations assumed by cyclosporin A in...
14.
Wu J, Puppala D, Feng X, Monetti M, Lapworth A, Geoghegan K
J Biol Chem
. 2013 Nov;
288(50):35904-12.
PMID: 24187138
AMP-activated protein kinase (AMPK) is a heterotrimeric enzyme that senses and governs changes in the cellular energy balance represented by concentrations of AMP, ADP, and ATP. Each of its three...
15.
Geoghegan K, Song X, Hoth L, Feng X, Shanker S, Quazi A, et al.
Protein Expr Purif
. 2012 Oct;
87(1):27-34.
PMID: 23069765
The T helper cell-derived cytokine interleukin-17A (IL-17A) is a variably glycosylated disulfide-linked homodimer of 34-38 kDa. Its polypeptide monomer contains one canonical N-glycosylation site at Asn68, and human recombinant IL-17A...
16.
Geoghegan K, Varghese A, Feng X, Bessire A, Conboy J, Ruggeri R, et al.
Biochemistry
. 2012 Feb;
51(10):2065-77.
PMID: 22352991
Myeloperoxidase (MPO) is known to be inactivated and covalently modified by treatment with hydrogen peroxide and agents similar to 3-(2-ethoxypropyl)-2-thioxo-2,3-dihydro-1H-purin-6(9H)-one (1), a 254.08 Da derivative of 2-thioxanthine. Peptide mapping by...
17.
Han S, Caspers N, Zaniewski R, Lacey B, Tomaras A, Feng X, et al.
J Am Chem Soc
. 2011 Nov;
133(50):20536-45.
PMID: 22050378
Multi-drug-resistant forms of the Gram-negative pathogen Acinetobacter baumannii are an emerging threat to human health and further complicate the general problem of treating serious bacterial infections. Meeting this challenge requires...
18.
Miyanaga A, Janso J, McDonald L, He M, Liu H, Barbieri L, et al.
J Am Chem Soc
. 2011 Aug;
133(34):13311-3.
PMID: 21815669
The pyrroloquinoline alkaloid family of natural products, which includes the immunosuppressant lymphostin, has long been postulated to arise from tryptophan. We now report the molecular basis of lymphostin biosynthesis in...
19.
Investigation of the biosynthesis of the pipecolate moiety of neuroprotective polyketide meridamycin
Jiang H, Haltli B, Feng X, Cai P, Summers M, Lotvin J, et al.
J Antibiot (Tokyo)
. 2011 May;
64(8):533-8.
PMID: 21610714
Biogenesis of the pipecolate moiety of neuroprotective agent meridamycin in Streptomyces sp. NRRL30748 was investigated in feeding studies using lysine specifically labeled with (15)N at the α-amino or the ε-amino...
20.
Geoghegan K, Feng X, Chang J, Kelleher K, Wu P, Lin L, et al.
Protein Expr Purif
. 2010 Oct;
76(1):72-8.
PMID: 20888915
When the 34 kDa kinase domain of human spleen tyrosine kinase (Syk-KD) was expressed as a C-terminally His-tagged protein in baculovirus-infected Sf-21 insect cells, the purified protein included two forms...