William E McIntire
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Explore the profile of William E McIntire including associated specialties, affiliations and a list of published articles.
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23
Citations
424
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Recent Articles
1.
McIntire W, Purdy M, Leonhardt S, Kucharska I, Hanson M, Poulos S, et al.
Res Sq
. 2024 Feb;
PMID: 38343806
Adenosine A receptors (AAR) evoke pleiotropic intracellular signaling events via activation of the stimulatory heterotrimeric G protein, Gs. Here, we used cryoEM to solve the agonist-bound structure of AAR in...
2.
Leonhardt S, Purdy M, Grover J, Yang Z, Poulos S, McIntire W, et al.
Nat Commun
. 2023 Jul;
14(1):4368.
PMID: 37474505
The host proteins SERINC3 and SERINC5 are HIV-1 restriction factors that reduce infectivity when incorporated into the viral envelope. The HIV-1 accessory protein Nef abrogates incorporation of SERINCs via binding...
3.
McIntire W
J Gen Physiol
. 2022 Mar;
154(5).
PMID: 35333292
Representing ∼5% of the human genome, G-protein-coupled receptors (GPCRs) are a primary target for drug discovery; however, the molecular details of how they couple to heterotrimeric G protein subunits are...
4.
Joksimovic S, Evans J, McIntire W, Orestes P, Barrett P, Jevtovic-Todorovic V, et al.
Front Cell Neurosci
. 2021 Jan;
14:605312.
PMID: 33384586
Our previous studies implicated glycosylation of the Ca3.2 isoform of T-type Ca channels (T-channels) in the development of Type 2 painful peripheral diabetic neuropathy (PDN). Here we investigated biophysical mechanisms...
5.
Khan A, Jagielnicki M, McIntire W, Purdy M, Dharmarajan V, Griffin P, et al.
Cell Rep
. 2020 Apr;
31(3):107482.
PMID: 32320665
Gap junction channels (GJCs) mediate intercellular communication and are gated by numerous conditions such as pH. The electron cryomicroscopy (cryo-EM) structure of Cx26 GJC at physiological pH recapitulates previous GJC...
6.
Yao J, McHedlishvili D, McIntire W, Guagliardo N, Erisir A, Coburn C, et al.
Hypertension
. 2017 Jun;
70(2):347-356.
PMID: 28630209
Ca drives aldosterone synthesis in the cytosolic and mitochondrial compartments of the adrenal zona glomerulosa cell. Membrane potential across each of these compartments regulates the amplitude of the Ca signal;...
7.
Bennett B, Purdy M, Baker K, Acharya C, McIntire W, Stevens R, et al.
Nat Commun
. 2016 Jan;
7:8770.
PMID: 26753910
Gap junction channels mediate intercellular signalling that is crucial in tissue development, homeostasis and pathologic states such as cardiac arrhythmias, cancer and trauma. To explore the mechanism by which Ca(2+)...
8.
Purdy M, Bennett B, McIntire W, Khan A, Kasson P, Yeager M
Curr Opin Struct Biol
. 2014 Sep;
27:138-48.
PMID: 25238653
Three vignettes exemplify the potential of combining EM and X-ray crystallographic data with molecular dynamics (MD) simulation to explore the architecture, dynamics and functional properties of multicomponent, macromolecular complexes. The...
9.
Orestes P, Osuru H, McIntire W, Jacus M, Salajegheh R, Jagodic M, et al.
Diabetes
. 2013 Jul;
62(11):3828-38.
PMID: 23835327
It has been established that Ca(V)3.2 T-type voltage-gated calcium channels (T-channels) play a key role in the sensitized (hyperexcitable) state of nociceptive sensory neurons (nociceptors) in response to hyperglycemia associated...
10.
Wang D, Sherman N, Shannon J, Leonhardt S, Mayeenuddin L, Yeager M, et al.
Biochemistry
. 2010 Dec;
50(2):207-20.
PMID: 21128647
Characterization of G protein βγ dimer isoform expression in different cellular contexts has been impeded by low levels of protein expression, broad isoform heterogeneity, and antibodies of limited specificity, sensitivity,...