Paula Q Barrett
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Explore the profile of Paula Q Barrett including associated specialties, affiliations and a list of published articles.
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39
Citations
1244
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Recent Articles
1.
Borges K, Little 3rd D, de Almeida Magalhaes T, Ribeiro C, Dumontet T, Lapensee C, et al.
bioRxiv
. 2024 Sep;
PMID: 39229119
The steroid hormone aldosterone, produced by the zona glomerulosa (zG) of the adrenal gland, is a master regulator of plasma electrolytes and blood pressure. While aldosterone control by the renin-angiotensin...
2.
Gancayco C, Gerding M, Breault D, Beenhakker M, Barrett P, Guagliardo N
Hypertension
. 2022 Sep;
79(11):2552-2564.
PMID: 36129175
Background: Ion channel mutations in calcium regulating genes strongly associate with AngII (angiotensin II)-independent aldosterone production. Here, we used an established mouse model of in vivo aldosterone autonomy, -driven deletion...
3.
Leng S, Carlone D, Guagliardo N, Barrett P, Breault D
Mol Cell Endocrinol
. 2021 Apr;
530:111287.
PMID: 33891993
How morphology informs function is a fundamental biological question. Here, we review the morphological features of the adrenal zona glomerulosa (zG), highlighting recent cellular and molecular discoveries that govern its...
4.
Narahari A, Kreutzberger A, Gaete P, Chiu Y, Leonhardt S, Medina C, et al.
Elife
. 2021 Jan;
10.
PMID: 33410749
Pannexin 1 (Panx1) is a membrane channel implicated in numerous physiological and pathophysiological processes via its ability to support release of ATP and other cellular metabolites for local intercellular signaling....
5.
Joksimovic S, Evans J, McIntire W, Orestes P, Barrett P, Jevtovic-Todorovic V, et al.
Front Cell Neurosci
. 2021 Jan;
14:605312.
PMID: 33384586
Our previous studies implicated glycosylation of the Ca3.2 isoform of T-type Ca channels (T-channels) in the development of Type 2 painful peripheral diabetic neuropathy (PDN). Here we investigated biophysical mechanisms...
6.
Barrett P, Guagliardo N, Bayliss D
Annu Rev Physiol
. 2020 Nov;
83:451-475.
PMID: 33176563
Aldosterone excess is a pathogenic factor in many hypertensive disorders. The discovery of numerous somatic and germline mutations in ion channels in primary hyperaldosteronism underscores the importance of plasma membrane...
7.
DeLalio L, Masati E, Mendu S, Ruddiman C, Yang Y, Johnstone S, et al.
Kidney Int
. 2020 May;
98(3):630-644.
PMID: 32446934
Kidney function and blood pressure homeostasis are regulated by purinergic signaling mechanisms. These autocrine/paracrine signaling pathways are initiated by the release of cellular ATP, which influences kidney hemodynamics and steady-state...
8.
Pignatti E, Leng S, Yuchi Y, Borges K, Guagliardo N, Shah M, et al.
Cell Rep
. 2020 Apr;
31(3):107524.
PMID: 32320669
Activating mutations in the canonical Wnt/β-catenin pathway are key drivers of hyperplasia, the gateway for tumor development. In a wide range of tissues, this occurs primarily through enhanced effects on...
9.
Leng S, Pignatti E, Khetani R, Shah M, Xu S, Miao J, et al.
Nat Commun
. 2020 Apr;
11(1):1680.
PMID: 32245949
Rosettes are widely used in epithelial morphogenesis during embryonic development and organogenesis. However, their role in postnatal development and adult tissue maintenance remains largely unknown. Here, we show zona glomerulosa...
10.
Guagliardo N, Klein P, Gancayco C, Lu A, Leng S, Makarem R, et al.
Nat Commun
. 2020 Apr;
11(1):1679.
PMID: 32245948
Aldosterone-producing zona glomerulosa (zG) cells of the adrenal gland arrange in distinct multi-cellular rosettes that provide a structural framework for adrenal cortex morphogenesis and plasticity. Whether this cyto-architecture also plays...