William E McIntire
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Explore the profile of William E McIntire including associated specialties, affiliations and a list of published articles.
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23
Citations
424
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Recent Articles
11.
McIntire W
Neurosignals
. 2009 Feb;
17(1):82-99.
PMID: 19212142
Heterotrimeric G proteins, composed of an alpha, beta and gamma subunit, represent one of the most important and dynamic families of signaling proteins. As a testament to the significance of...
12.
Hu C, DePuy S, Yao J, McIntire W, Barrett P
J Biol Chem
. 2009 Jan;
284(12):7465-73.
PMID: 19131331
Low voltage-activated (LVA), T-type, calcium channels mediate diverse biological functions and are inhibited by Gbetagamma dimers, yet the molecular events required for channel inhibition remain unknown. Here, we identify protein...
13.
Wu Y, Buranda T, Simons P, Lopez G, McIntire W, Garrison J, et al.
Anal Biochem
. 2007 Oct;
371(1):10-20.
PMID: 17904091
We have used rapid-mix flow cytometry to analyze the early subsecond dynamics of the disassembly of ternary complexes of G protein-coupled receptors (GPCRs) immobilized on beads to examine individual steps...
14.
McIntire W, MacCleery G, Murphree L, Kerchner K, Linden J, Garrison J
Biochemistry
. 2006 Sep;
45(38):11616-31.
PMID: 16981721
Ggamma11 is an unusual guanine nucleotide-binding regulatory protein (G protein) subunit. To study the effect of different Gbeta-binding partners on gamma11 function, four recombinant betagamma dimers, beta1gamma2, beta4gamma2, beta1gamma11, and...
15.
Chen X, Talley E, Patel N, Gomis A, McIntire W, Dong B, et al.
Proc Natl Acad Sci U S A
. 2006 Feb;
103(9):3422-7.
PMID: 16492788
Two-pore-domain K(+) channels provide neuronal background currents that establish resting membrane potential and input resistance; their modulation provides a prevalent mechanism for regulating cellular excitability. The so-called TASK channel subunits...
16.
Mayeenuddin L, McIntire W, Garrison J
J Biol Chem
. 2005 Nov;
281(4):1913-20.
PMID: 16301321
P-Rex1 is a specific guanine nucleotide exchange factor (GEF) for Rac, which is present in high abundance in brain and hematopoietic cells. P-Rex1 is dually regulated by phosphatidylinositol (3,4,5)-trisphosphate and...
17.
Kerchner K, Clay R, McCleery G, Watson N, McIntire W, Myung C, et al.
J Biol Chem
. 2004 Aug;
279(43):44554-62.
PMID: 15322106
The ability of G protein alpha and betagamma subunits to activate the p110gamma isoform of phosphatidylinositol 3-kinase (PtdIns 3-kinase) was examined using pure, recombinant G proteins and the p101/p110gamma form...
18.
Lukov G, Myung C, McIntire W, Shao J, Zimmerman S, Garrison J, et al.
Biochemistry
. 2004 May;
43(19):5651-60.
PMID: 15134439
Phosducin (Pdc) and phosducin-like protein (PhLP) regulate G protein-mediated signaling by binding to the betagamma subunit complex of heterotrimeric G proteins (Gbetagamma) and removing the dimer from cell membranes. The...
19.
Simons P, Shi M, Foutz T, Cimino D, Lewis J, Buranda T, et al.
Mol Pharmacol
. 2003 Oct;
64(5):1227-38.
PMID: 14573773
G protein-coupled receptors form a ternary complex of ligand, receptor, and G protein heterotrimer (LRG) during signal transduction from the outside to the inside of a cell. Our goal was...
20.
Hollmann M, McIntire W, Garrison J, Durieux M
Anesthesiology
. 2002 Dec;
97(6):1451-7.
PMID: 12459671
Background: Local anesthetics have been shown to selectively inhibit functioning of Xenopus laevis Gq proteins. It is not known whether a similar interaction exists with mammalian G proteins. The goal...