William C Sessa
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Explore the profile of William C Sessa including associated specialties, affiliations and a list of published articles.
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Articles
235
Citations
13622
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Recent Articles
1.
Groarke J, Sessa W, Saxena A
N Engl J Med
. 2025 Mar;
392(10):1036-1037.
PMID: 40043245
No abstract available.
2.
Lee S, Schleer H, Park H, Jang E, Boyer M, Tao B, et al.
Nat Cardiovasc Res
. 2024 Aug;
2(5):438-448.
PMID: 39196046
Low-density lipoprotein (LDL) accumulation in the arterial wall contributes to atherosclerosis initiation and progression. Activin A receptor-like type 1 (ACVRL1, called activin-like kinase receptor (ALK1)) is a recently identified receptor...
3.
Zhou W, Ghersi J, Ristori E, Semanchik N, Prendergast A, Zhang R, et al.
Development
. 2024 Aug;
151(17).
PMID: 39101673
The dorsal aorta (DA) is the first major blood vessel to develop in the embryonic cardiovascular system. Its formation is governed by a coordinated process involving the migration, specification, and...
4.
Gratton J, Lin M, Yu J, Weiss E, Jiang Z, Fairchild T, et al.
Cancer Cell
. 2024 May;
42(6):1127.
PMID: 38821059
No abstract available.
5.
Jiang Q, Song G, He L, Li X, Jiang B, Wang Q, et al.
Kidney Int
. 2024 May;
106(3):419-432.
PMID: 38797325
ZFYVE21 is an ancient, endosome-associated protein that is highly expressed in endothelial cells (ECs) but whose function(s) in vivo are undefined. Here, we identified ZFYVE21 as an essential regulator of...
6.
Boutagy N, Gamez-Mendez A, Fowler J, Zhang H, Chaube B, Esplugues E, et al.
J Clin Invest
. 2024 Jan;
134(4).
PMID: 38175710
Blood vessels are continually exposed to circulating lipids, and elevation of ApoB-containing lipoproteins causes atherosclerosis. Lipoprotein metabolism is highly regulated by lipolysis, largely at the level of the capillary endothelium...
7.
Nguyen T, Rahman N, Sessa W, Lee M
Front Cardiovasc Med
. 2023 Nov;
10:1279868.
PMID: 38034389
Objective: We have previously demonstrated the importance of the Akt-eNOS substrate-kinase relationship, as defective postnatal angiogenesis characteristic of global Akt1-null mice is rescued when bred to 'gain-of-function' eNOS S1176D mutant...
8.
Singh A, Chaube B, Citrin K, Fowler J, Lee S, Catarino J, et al.
bioRxiv
. 2023 Nov;
PMID: 38014178
Obesity-linked fatty liver is a significant risk factor for hepatocellular carcinoma (HCC); however, the molecular mechanisms underlying the transition from non-alcoholic fatty liver disease (NAFLD) to HCC remains unclear. The...
9.
Boutagy N, Fowler J, Grabinska K, Cardone R, Sun Q, Vazquez K, et al.
Proc Natl Acad Sci U S A
. 2023 Sep;
120(38):e2218150120.
PMID: 37695914
The endothelium is a major target of the proinflammatory cytokine, tumor necrosis factor alpha (TNFα). Exposure of endothelial cells (EC) to proinflammatory stimuli leads to an increase in mitochondrial metabolism;...
10.
SREBP2 regulates the endothelial response to cytokines via direct transcriptional activation of KLF6
Fowler J, Boutagy N, Zhang R, Horikami D, Whalen M, Romanoski C, et al.
J Lipid Res
. 2023 Jul;
64(8):100411.
PMID: 37437844
The transcription factor SREBP2 is the main regulator of cholesterol homeostasis and is central to the mechanism of action of lipid-lowering drugs, such as statins, which are responsible for the...