Carlos Fernandez-Hernando
Overview
Explore the profile of Carlos Fernandez-Hernando including associated specialties, affiliations and a list of published articles.
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188
Citations
9647
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Recent Articles
1.
Zhang H, Saenz de Urturi D, Fernandez-Tussy P, Huang Y, Jovin D, Zhang X, et al.
Proc Natl Acad Sci U S A
. 2025 Mar;
122(10):e2417512122.
PMID: 40035761
Vascular smooth muscle cells (VSMC) are the most abundant cell type in the artery's media layer and regulate vascular tone and lesion remodeling during atherogenesis. Like monocyte-derived macrophages, VSMCs accumulate...
2.
Citrin K, Chaube B, Fernandez-Hernando C, Suarez Y
Trends Endocrinol Metab
. 2024 Dec;
PMID: 39672762
Endothelial cells (ECs) form the inner lining of blood vessels that is crucial for vascular function and homeostasis. They regulate vascular tone, oxidative stress, and permeability. Dysfunction leads to increased...
3.
Srivastava S, Zhou H, Shenoi R, Morris M, Lainez-Mas B, Goedeke L, et al.
Sci Adv
. 2024 Dec;
10(49):eadn6068.
PMID: 39630889
Angiopoietin-like 4 (ANGPTL4), a key protein involved in lipoprotein metabolism, has diverse effects. There is an association between Angptl4 and diabetic kidney disease; however, this association has not been well...
4.
Tate M, Wijeratne H, Kim B, Philtjens S, You Y, Lee D, et al.
Alzheimers Dement
. 2024 Sep;
20(11):7805-7818.
PMID: 39345217
Introduction: Rare variants in ABCA1 increase the risk of developing Alzheimer's disease (AD). ABCA1 facilitates the lipidation of apolipoprotein E (apoE). This study investigated whether microRNA-33 (miR-33)-mediated regulation of this...
5.
Joshi D, Coon B, Chakraborty R, Deng H, Yang Z, Babar M, et al.
Nat Cardiovasc Res
. 2024 Sep;
3(9):1035-1048.
PMID: 39232138
Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of mortality worldwide. Laminar shear stress from blood flow, sensed by vascular endothelial cells, protects from ASCVD by upregulating the transcription factors...
6.
Lee S, Schleer H, Park H, Jang E, Boyer M, Tao B, et al.
Nat Cardiovasc Res
. 2024 Aug;
2(5):438-448.
PMID: 39196046
Low-density lipoprotein (LDL) accumulation in the arterial wall contributes to atherosclerosis initiation and progression. Activin A receptor-like type 1 (ACVRL1, called activin-like kinase receptor (ALK1)) is a recently identified receptor...
7.
Fernandez-Tussy P, Cardelo M, Zhang H, Sun J, Price N, Boutagy N, et al.
JCI Insight
. 2024 Aug;
9(19).
PMID: 39190492
The complexity of the mechanisms underlying metabolic dysfunction-associated steatotic liver disease (MASLD) progression remains a significant challenge for the development of effective therapeutics. miRNAs have shown great promise as regulators...
8.
Sun J, Esplugues E, Bort A, Cardelo M, Ruz-Maldonado I, Fernandez-Tussy P, et al.
Nat Metab
. 2024 Apr;
6(4):741-763.
PMID: 38664583
Due to the rise in overnutrition, the incidence of obesity-induced hepatocellular carcinoma (HCC) will continue to escalate; however, our understanding of the obesity to HCC developmental axis is limited. We...
9.
Price N, Fernandez-Tussy P, Varela L, Cardelo M, Shanabrough M, Aryal B, et al.
Nat Commun
. 2024 Mar;
15(1):2131.
PMID: 38459068
AgRP neurons drive hunger, and excessive nutrient intake is the primary driver of obesity and associated metabolic disorders. While many factors impacting central regulation of feeding behavior have been established,...
10.
Ruz-Maldonado I, Gonzalez J, Zhang H, Sun J, Bort A, Kabir I, et al.
Nat Commun
. 2024 Feb;
15(1):1247.
PMID: 38341404
Midlobular hepatocytes are proposed to be the most plastic hepatic cell, providing a reservoir for hepatocyte proliferation during homeostasis and regeneration. However, other mechanisms beyond hyperplasia have been little explored...