Wilfred A van der Donk
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Explore the profile of Wilfred A van der Donk including associated specialties, affiliations and a list of published articles.
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309
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10531
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Recent Articles
11.
Chen J, van der Donk W
Curr Opin Chem Biol
. 2024 May;
80:102467.
PMID: 38772214
Multinuclear non-heme iron dependent oxidative enzymes (MNIOs), formerly known as domain of unknown function 692 (DUF692), are involved in the post-translational modification of peptides during the biosynthesis of peptide-based natural...
12.
Ramos Figueroa J, Zhu L, van der Donk W
J Am Chem Soc
. 2024 May;
146(20):14235-14245.
PMID: 38719200
Pyrroloiminoquinone-containing natural products have long been known for their biological activities. They are derived from tryptophan, but their biosynthetic pathways have remained elusive. Studies on the biosynthetic gene cluster (BGC)...
13.
Nguyen D, Mitchell D, van der Donk W
ACS Catal
. 2024 Apr;
14(7):4536-4553.
PMID: 38601780
A revolution in the field of biocatalysis has enabled scalable access to compounds of high societal values using enzymes. The construction of biocatalytic routes relies on the reservoir of available...
14.
Ramos Figueroa J, Zhu L, van der Donk W
bioRxiv
. 2024 Apr;
PMID: 38559119
Pyrroloiminoquinone containing natural products have long been known for their biological activities. They are derived from tryptophan, but their biosynthetic pathways have remained elusive. Studies on the biosynthetic gene cluster...
15.
Eslami S, van der Donk W
ACS Bio Med Chem Au
. 2024 Feb;
4(1):20-36.
PMID: 38404746
Ribosomally synthesized and post-translationally modified peptides (RiPPs) have received much attention in recent years because of their promising bioactivities and the portability of their biosynthetic pathways. Heterologous expression studies of...
16.
Zhang Z, Wu C, Moreira R, Dorantes D, Pappas T, Sundararajan A, et al.
ACS Chem Biol
. 2024 Jan;
19(2):357-369.
PMID: 38293740
Recent advances in sequencing techniques unveiled the vast potential of ribosomally synthesized and post-translationally modified peptides (RiPPs) encoded in microbiomes. Class I lantibiotics such as nisin A, widely used as...
17.
Zhang Z, Cole C, Lin H, Wu C, Haro F, McSpadden E, et al.
bioRxiv
. 2024 Jan;
PMID: 38234830
The intestinal microbiota is composed of hundreds of distinct microbial species that interact with each other and their mammalian host. Antibiotic exposure dramatically impacts microbiota compositions and leads to acquisition...
18.
Luo Y, Xu S, Frerk A, van der Donk W
Anal Chem
. 2024 Jan;
96(4):1767-1773.
PMID: 38232355
Lanthipeptides make up a large group of natural products that belong to the ribosomally synthesized and post-translationally modified peptides (RiPPs). Lanthipeptides contain lanthionine and methyllanthionine bis-amino acids that have varying...
19.
Yu Y, van der Donk W
bioRxiv
. 2024 Jan;
PMID: 38187666
A subset of nonribosomal peptide synthetases (NRPSs) and polyketide synthases (PKSs) are encoded in their biosynthetic gene clusters (BGCs) with enzymes annotated as lantibiotic dehydratases. The functions of these putative...
20.
Wu C, Lower B, Moreira R, Dorantes D, Le T, Giurgiu C, et al.
Front Microbiol
. 2023 Nov;
14:1247222.
PMID: 38029153
Addressing the current antibiotic-resistance challenge would be aided by the identification of compounds with novel mechanisms of action. Epilancin 15X, a lantibiotic produced by 15 × 154, displays antimicrobial activity...