Wilfred A van der Donk
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Explore the profile of Wilfred A van der Donk including associated specialties, affiliations and a list of published articles.
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309
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10531
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Recent Articles
1.
Saha N, Vidya F, Luo Y, van der Donk W, Agarwal V
Org Lett
. 2025 Jan;
27(4):984-988.
PMID: 39819031
Natural product biosynthesis is nature's tinkering ground for developing new enzymes that can achieve chemical transformations that are outside the purview of traditional chemical catalysis. Herein we describe a genome...
2.
Desormeaux E, Barksdale G, van der Donk W
ACS Catal
. 2024 Dec;
14(24):18310-18321.
PMID: 39722886
Lanthipeptides are ribosomally synthesized and post-translationally modified peptides (RiPPs) characterized by the presence of thioether cross-links called lanthionine and methyllanthionine, formed by dehydration of Ser/Thr residues and Michael-type addition of...
3.
Liang H, Luo Y, van der Donk W
Biochemistry
. 2024 Sep;
63(19):2493-2505.
PMID: 39271288
Modification of the N- and C-termini of peptides enhances their stability against degradation by exopeptidases. The biosynthetic pathways of many peptidic natural products feature enzymatic modification of their termini, and...
4.
Moreira R, Yang Y, Luo Y, Gilmore M, van der Donk W
RSC Chem Biol
. 2024 Sep;
PMID: 39268544
Here we describe bibacillin 1 - a two-component lantibiotic from . The peptides that comprise bibacillin 1 are modified by a class II lanthipeptide synthetase Bib1M producing two peptides with...
5.
Vermeulen R, van Staden A, Ollewagen T, van Zyl L, Luo Y, van der Donk W, et al.
ACS Omega
. 2024 Jul;
9(29):31832-31841.
PMID: 39072090
Viridisin A1 and A2 were previously heterologously expressed, purified, and characterized as ribosomally produced and post-translationally modified lanthipeptides. Such lanthipeptide operons are surprisingly common in Gram-negative bacteria, although their expression...
6.
Yu Y, van der Donk W
ACS Cent Sci
. 2024 Jul;
10(6):1242-1250.
PMID: 38947204
A subset of nonribosomal peptide synthetases (NRPSs) and polyketide synthases (PKSs) are encoded in their biosynthetic gene clusters (BGCs) with enzymes annotated as lantibiotic dehydratases. The functions of these putative...
7.
Eslami S, Padhi C, Rahman I, van der Donk W
ACS Synth Biol
. 2024 Jun;
13(7):2128-2140.
PMID: 38925629
Cyclic peptides, such as most ribosomally synthesized and post-translationally modified peptides (RiPPs), represent a burgeoning area of interest in therapeutic and biotechnological research because of their conformational constraints and reduced...
8.
Le T, Zhang D, Martini R, Biswas S, van der Donk W
Chem Commun (Camb)
. 2024 Jun;
60(51):6508-6511.
PMID: 38833296
Cyclotides and lanthipeptides are cyclic peptide natural products with promising bioengineering potential. No peptides have been isolated that contain both structural motifs defining these two families, an N-to-C cyclised backbone...
9.
Nguyen D, Zhu L, Gray D, Woods T, Padhi C, Flatt K, et al.
ACS Cent Sci
. 2024 May;
10(5):1022-1032.
PMID: 38799663
Advances in genome sequencing and bioinformatics methods have identified a myriad of biosynthetic gene clusters (BGCs) encoding uncharacterized molecules. By mining genomes for BGCs containing a prevalent peptide-binding domain used...
10.
Desormeaux E, van der Donk W
bioRxiv
. 2024 May;
PMID: 38798579
Lanthipeptides are ribosomally synthesized and post-translationally modified peptides characterized by the presence of thioether crosslinks. Class II lanthipeptide synthetases are bifunctional enzymes responsible for the multistep chemical modification of these...