Spencer C Peck
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Explore the profile of Spencer C Peck including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
245
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Recent Articles
1.
Bumpers Q, Pipal R, Benz-Weeden A, Brewster 2nd J, Cook A, Crooks A, et al.
J Med Chem
. 2024 Aug;
67(16):14466-14477.
PMID: 39088797
Mesenchymal-epithelial transition factor (MET) is a receptor tyrosine kinase that serves a critical function in numerous developmental, morphogenic, and proliferative signaling pathways. If dysregulated, MET has been shown to be...
2.
Peck S, Denger K, Burrichter A, Irwin S, Balskus E, Schleheck D
Proc Natl Acad Sci U S A
. 2019 Feb;
116(8):3171-3176.
PMID: 30718429
Hydrogen sulfide (HS) production in the intestinal microbiota has many contributions to human health and disease. An important source of HS in the human gut is anaerobic respiration of sulfite...
3.
Bougioukou D, Ting C, Peck S, Mukherjee S, van der Donk W
Org Biomol Chem
. 2019 Jan;
17(4):822-829.
PMID: 30608108
The C-terminal domain of the dehydrophos biosynthetic enzyme DhpH (DhpH-C) catalyzes the condensation of Leu-tRNALeu with (R)-1-aminoethylphosphonate, the aminophosphonate analog of alanine called Ala(P). The product of this reaction, Leu-Ala(P),...
4.
Born D, Ulrich E, Ju K, Peck S, van der Donk W, Drennan C
Science
. 2017 Dec;
358(6368):1336-1339.
PMID: 29217579
Methylphosphonate synthase (MPnS) produces methylphosphonate, a metabolic precursor to methane in the upper ocean. Here, we determine a 2.35-angstrom resolution structure of MPnS and discover that it has an unusual...
5.
Peck S, Wang C, Dassama L, Zhang B, Guo Y, Rajakovich L, et al.
J Am Chem Soc
. 2017 Jan;
139(5):2045-2052.
PMID: 28092705
Activation of O-H bonds by inorganic metal-oxo complexes has been documented, but no cognate enzymatic process is known. Our mechanistic analysis of 2-hydroxyethylphosphonate dioxygenase (HEPD), which cleaves the C1-C2 bond...
6.
Peck S, van der Donk W
J Biol Inorg Chem
. 2016 Oct;
22(2-3):381-394.
PMID: 27783267
This review discusses the current mechanistic understanding of a group of mononuclear non-heme iron-dependent enzymes that catalyze four-electron oxidation of their organic substrates without the use of any cofactors or...
7.
Zhu H, Peck S, Bonnot F, van der Donk W, Klinman J
J Am Chem Soc
. 2015 Aug;
137(33):10448-51.
PMID: 26267117
Nonheme iron oxygenases that carry out four-electron oxidations of substrate have been proposed to employ iron(III) superoxide species to initiate this reaction [Paria, S.; Que, L.; Paine, T. K. Angew....
8.
Peck S, Chekan J, Ulrich E, Nair S, van der Donk W
J Am Chem Soc
. 2015 Feb;
137(9):3217-20.
PMID: 25699631
2-Hydroxyethylphosphonate dioxygenase (HEPD) and methylphosphonate synthase (MPnS) are nonheme iron oxygenases that both catalyze the carbon-carbon bond cleavage of 2-hydroxyethylphosphonate but generate different products. Substrate labeling experiments led to a...
9.
Peck S, Kim S, Evans B, van der Donk W
Medchemcomm
. 2014 Nov;
3(8):967-970.
PMID: 25400901
No abstract available.
10.
Agarwal V, Peck S, Chen J, Borisova S, Chekan J, van der Donk W, et al.
Chem Biol
. 2013 Dec;
21(1):125-35.
PMID: 24361046
Phosphonates (C-PO₃²⁻) have applications as antibiotics, herbicides, and detergents. In some environments, these molecules represent the predominant source of phosphorus, and several microbes have evolved dedicated enzymatic machineries for phosphonate...