Douglas A Mitchell
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Explore the profile of Douglas A Mitchell including associated specialties, affiliations and a list of published articles.
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128
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5768
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Recent Articles
1.
Zdouc M, Blin K, Louwen N, Navarro J, Loureiro C, Bader C, et al.
Nucleic Acids Res
. 2024 Dec;
53(D1):D678-D690.
PMID: 39657789
Specialized or secondary metabolites are small molecules of biological origin, often showing potent biological activities with applications in agriculture, engineering and medicine. Usually, the biosynthesis of these natural products is...
2.
Clark J, Mi X, Mitchell D, Shukla D
Digit Discov
. 2024 Dec;
4(2):343-354.
PMID: 39649639
Ribosomally synthesized and post-translationally modified peptide (RiPP) biosynthetic enzymes often exhibit promiscuous substrate preferences that cannot be reduced to simple rules. Large language models are promising tools for predicting the...
3.
Barrett S, Yin S, Jordan P, Brunson J, Gordon-Nunez J, Costa Machado da Cruz G, et al.
Nat Chem Biol
. 2024 Sep;
21(3):412-419.
PMID: 39261643
Lasso peptides are a diverse class of naturally occurring, highly stable molecules kinetically trapped in a distinctive [1]rotaxane conformation. How the ATP-dependent lasso cyclase constrains a relatively unstructured substrate peptide...
4.
Barrett S, Mitchell D
Trends Genet
. 2024 Sep;
40(11):950-968.
PMID: 39218755
Lasso peptides are a large and sequence-diverse class of ribosomally synthesized and post-translationally modified peptide (RiPP) natural products characterized by their slip knot-like shape. These unique, highly stable peptides are...
5.
Nguyen D, Zhu L, Gray D, Woods T, Padhi C, Flatt K, et al.
ACS Cent Sci
. 2024 May;
10(5):1022-1032.
PMID: 38799663
Advances in genome sequencing and bioinformatics methods have identified a myriad of biosynthetic gene clusters (BGCs) encoding uncharacterized molecules. By mining genomes for BGCs containing a prevalent peptide-binding domain used...
6.
Woodard A, Peccati F, Navo C, Jimenez-Oses G, Mitchell D
J Am Chem Soc
. 2024 May;
146(20):14328-14340.
PMID: 38728535
The Gram-negative selective antibiotic darobactin A has attracted interest owing to its intriguing fused bicyclic structure and unique targeting of the outer membrane protein BamA. Darobactin, a ribosomally synthesized and...
7.
Lee A, Carter R, Imani A, Dommaraju S, Hudson G, Mitchell D, et al.
ACS Chem Biol
. 2024 May;
19(5):1116-1124.
PMID: 38695893
Borosins are ribosomally synthesized and post-translationally modified peptides (RiPPs) containing backbone α--methylations. These modifications confer favorable pharmacokinetic properties including increased membrane permeability and resistance to proteolytic degradation. Previous studies have...
8.
Shi C, Patel V, Mitchell D, Zhao H
Chembiochem
. 2024 Apr;
25(12):e202400212.
PMID: 38648232
The β-hemolytic factor streptolysin S (SLS) is an important linear azol(in)e-containing peptide (LAP) that contributes significantly to the virulence of Streptococcus pyogenes. Despite its discovery 85 years ago, SLS has...
9.
Nguyen D, Mitchell D, van der Donk W
ACS Catal
. 2024 Apr;
14(7):4536-4553.
PMID: 38601780
A revolution in the field of biocatalysis has enabled scalable access to compounds of high societal values using enzymes. The construction of biocatalytic routes relies on the reservoir of available...
10.
Ren H, Huang C, Pan Y, Dommaraju S, Cui H, Li M, et al.
Nat Chem
. 2024 Mar;
16(8):1320-1329.
PMID: 38528101
Recent efforts in genome mining of ribosomally synthesized and post-translationally modified peptides (RiPPs) have expanded the diversity of post-translational modification chemistries. However, RiPPs are rarely reported as hybrid molecules incorporating...