Weixue Wang
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Explore the profile of Weixue Wang including associated specialties, affiliations and a list of published articles.
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44
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Recent Articles
11.
Buckbinder L, St Jean Jr D, Tieu T, Ladd B, Hilbert B, Wang W, et al.
Cancer Discov
. 2023 Aug;
13(11):2432-2447.
PMID: 37623743
Significance: These preclinical data demonstrate that the mutant-selective, allosteric PI3Kα inhibitor STX-478 provides robust efficacy while avoiding the metabolic dysfunction associated with the nonselective inhibitor alpelisib. Our results support the...
12.
Zhang L, Wang W, Ge S, Li H, Bai M, Duan J, et al.
BMC Cancer
. 2023 Mar;
23(1):211.
PMID: 36872337
Background: The prognosis of patients with previously treated advanced gastric or gastroesophageal junction (GEJ) cancer remains poor. Given the robust development of immunotherapy and targeted therapy during the last decades,...
13.
Tichenor M, Wiener J, Rao N, Bacani G, Wei J, Pooley Deckhut C, et al.
J Med Chem
. 2022 Oct;
65(21):14326-14336.
PMID: 36314537
Bruton's tyrosine kinase (BTK) is a Tec family kinase that plays an essential role in B-cell receptor (BCR) signaling as well as Fcγ receptor signaling in leukocytes. Pharmacological inhibition of...
14.
Cisar J, Pietsch C, DeRatt L, Jacoby E, Kazmi F, Keohane C, et al.
J Med Chem
. 2022 Aug;
65(16):11241-11256.
PMID: 35925768
Acute myelogenous leukemia (AML), a disease of the blood and bone marrow, is characterized by the inability of myeloblasts to differentiate into mature cell types. Dihydroorotate dehydrogenase (DHODH) is an...
15.
Huang H, Zhou R, Wen H, Xu Z, Zhang S, Wang W, et al.
Bioorg Med Chem Lett
. 2022 Jun;
72:128861.
PMID: 35718103
As a mitochondrial signature phospholipid, cardiolipin (CL) is required for membrane structure, respiration, dynamics, fragmentation, and mitophagy. Alteration of CL by reactive oxygen species (ROS) can cause mitochondrial dysfunction, which...
16.
Lercher L, Simon N, Bergmann A, Tauchert M, Bochmann D, Bashir T, et al.
SLAS Discov
. 2022 May;
27(5):306-313.
PMID: 35513262
The dysregulation of the PRC1/2 complex plays a key role in lineage plasticity in prostate cancer and may be required to maintain neuroendocrine phenotype. [1] CBX2, a key component of...
17.
Zhang H, Wang M, He Y, Deng T, Liu R, Wang W, et al.
Cell Death Dis
. 2021 Nov;
12(12):1116.
PMID: 34845198
Cancer stem cells (CSCs) are an important cause of tumor recurrence and drug resistance. As a new type of cell death that relies on iron ions and is strictly regulated...
18.
Jiang L, Xu J, Liu C, Gao N, Zhao J, Han X, et al.
Can Respir J
. 2021 Oct;
2021:6947037.
PMID: 34621458
Objective: We design a prospective control study on the utilization of transbronchial cryobiopsy guided by EBUS-GS (EBUS-GS-TBCB) to diagnose PPLs. Methods: PPLs were defined as pulmonary nodules or masses with...
19.
Wang W, Mevellec L, Liu A, Struble G, Miller R, Allen S, et al.
Biochemistry
. 2021 Oct;
60(41):3114-3124.
PMID: 34608799
Achieving selectivity across the human kinome is a major hurdle in kinase inhibitor drug discovery. Assays using active, phosphorylated protein kinases bias hits toward poorly selective inhibitors that bind within...
20.
Tichenor M, Wiener J, Rao N, Pooley Deckhut C, Barbay J, Kreutter K, et al.
ACS Med Chem Lett
. 2021 May;
12(5):782-790.
PMID: 34055226
Bruton's tyrosine kinase (BTK) is a cytoplasmic tyrosine kinase that plays a critical role in the activation of B cells, macrophages, and osteoclasts. Given the key role of these cell...