Stephen J Lippard
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Explore the profile of Stephen J Lippard including associated specialties, affiliations and a list of published articles.
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374
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11988
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Recent Articles
1.
Goldberg J, Lippard S
FEBS Lett
. 2022 Nov;
597(1):151-165.
PMID: 36416529
Mobile zinc is an abundant transition metal ion in the central nervous system, with pools of divalent zinc accumulating in regions of the brain engaged in sensory perception and memory...
2.
Replogle J, Zhou W, Amaro A, McFarland J, Villalobos-Ortiz M, Ryan J, et al.
Proc Natl Acad Sci U S A
. 2020 Nov;
117(48):30566-30576.
PMID: 33203674
Aneuploidy, defined as whole chromosome gains and losses, is associated with poor patient prognosis in many cancer types. However, the condition causes cellular stress and cell cycle delays, foremost in...
3.
Kong Y, Dreaden E, Morandell S, Zhou W, Dhara S, Sriram G, et al.
Nat Commun
. 2020 Aug;
11(1):4124.
PMID: 32807787
In response to DNA damage, a synthetic lethal relationship exists between the cell cycle checkpoint kinase MK2 and the tumor suppressor p53. Here, we describe the concept of augmented synthetic...
4.
Fadzen C, Wolfe J, Zhou W, Cho C, von Spreckelsen N, Hutchinson K, et al.
J Med Chem
. 2020 May;
63(13):6741-6747.
PMID: 32410451
Effective delivery to the brain limits the development of novel glioblastoma therapies. Here, we introduce conjugation between platinum(IV) prodrugs of cisplatin and perfluoroaryl peptide macrocycles to increase brain uptake. We...
5.
Lee M, Maji B, Manna D, Kahraman S, Elgamal R, Small J, et al.
J Am Chem Soc
. 2020 Mar;
142(14):6477-6482.
PMID: 32175731
The loss of insulin-producing β-cells is the central pathological event in type 1 and 2 diabetes, which has led to efforts to identify molecules to promote β-cell proliferation, protection, and...
6.
Zastrow M, Huang Z, Lippard S
ACS Chem Biol
. 2020 Jan;
15(2):396-406.
PMID: 31917534
We report a new series of small molecule-protein hybrid zinc sensors that combine genetic targetability with the spectroscopic profile of synthetic fluorophores. We functionalized the zinc sensor ZinPyr-1 (ZP1) with...
7.
Barandov A, Bartelle B, Williamson C, Loucks E, Lippard S, Jasanoff A
Nat Commun
. 2019 Feb;
10(1):897.
PMID: 30796208
Calcium ions are essential to signal transduction in virtually all cells, where they coordinate processes ranging from embryogenesis to neural function. Although optical probes for intracellular calcium imaging have been...
8.
Almaqwashi A, Zhou W, Naufer M, Riddell I, Yilmaz O, Lippard S, et al.
J Am Chem Soc
. 2019 Jan;
141(4):1537-1545.
PMID: 30599508
Phenanthriplatin, a monofunctional anticancer agent derived from cisplatin, shows significantly more rapid DNA covalent-binding activity compared to its parent complex. To understand the underlying molecular mechanism, we used single-molecule studies...
9.
Richardson C, Nolan E, Shoulders M, Lippard S
Biochemistry
. 2018 Nov;
57(50):6807-6815.
PMID: 30381945
Sensitive measurements of cellular Zn(II) uptake currently rely on quantitating radioactive emissions from cells treated with Zn(II). Here, we describe a straightforward and reliable method employing a stable isotope to...
10.
Han Y, Goldberg J, Lippard S, Palmer A
Sci Rep
. 2018 Oct;
8(1):15034.
PMID: 30302024
Small-molecule fluorescent probes are powerful and ubiquitous tools for measuring the concentration and distribution of analytes in living cells. However, accurate characterization of these analytes requires rigorous evaluation of cell-to-cell...