Alexandra Tanner
Overview
Explore the profile of Alexandra Tanner including associated specialties, affiliations and a list of published articles.
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9
Citations
20
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Recent Articles
1.
DeRatt L, Zhang Z, Pietsch E, Cisar J, Wang A, Wang C, et al.
Bioorg Med Chem Lett
. 2024 Sep;
113:129965.
PMID: 39284456
DHODH inhibition represents an attractive approach to overcome differentiation blockade for the treatment of AML. In a previous communication, we described our efforts leading to the discovery of compound 3...
2.
DeRatt L, Zhang Z, Pietsch C, Cisar J, Zhang X, Wang W, et al.
J Med Chem
. 2024 Jun;
67(13):11254-11272.
PMID: 38889244
Acute myelogenous leukemia (AML), a heterogeneous disease of the blood and bone marrow, is characterized by the inability of myeloblasts to differentiate into mature cell types. Dihydroorotate dehydrogenase (DHODH) is...
3.
DeRatt L, Pietsch E, Cisar J, Jacoby E, Kazmi F, Matico R, et al.
ACS Med Chem Lett
. 2024 Mar;
15(3):381-387.
PMID: 38505861
Dihydroorotate dehydrogenase (DHODH) is a mitochondrial enzyme that affects many aspects essential to cell proliferation and survival. Recently, DHODH has been identified as a potential target for acute myeloid leukemia...
4.
Tanner A, Urech A, Schulze H, Manser T
JMIR Rehabil Assist Technol
. 2023 Dec;
10:e48031.
PMID: 38145484
Background: Promoting the well-being of older adults in an aging society requires new solutions. One resource might be the use of social robots for group activities that promote physical and...
5.
Cisar J, Pietsch C, DeRatt L, Jacoby E, Kazmi F, Keohane C, et al.
J Med Chem
. 2022 Aug;
65(16):11241-11256.
PMID: 35925768
Acute myelogenous leukemia (AML), a disease of the blood and bone marrow, is characterized by the inability of myeloblasts to differentiate into mature cell types. Dihydroorotate dehydrogenase (DHODH) is an...
6.
Wolitzky-Taylor K, Glasner S, Tanner A, Ghahremani D, London E
Behav Res Ther
. 2022 Jan;
150:104032.
PMID: 35032700
Introduction: Cannabis use disorder (CUD) is a growing public health concern, and is highly comorbid with negative affective conditions such as anxiety and depression. Late adolescence and early adulthood represents...
7.
Snyder A, Sheridan C, Tanner A, Bickart K, Sullan M, Craske M, et al.
J Clin Med
. 2021 Feb;
10(4).
PMID: 33546148
Dysregulation of the autonomic nervous system (ANS) may play an important role in the development and maintenance of persistent post-concussive symptoms (PPCS). Post-injury breathing dysfunction, which is influenced by the...
8.
DeRatt L, Pietsch E, Tanner A, Shaffer P, Jacoby E, Wang W, et al.
Bioorg Med Chem Lett
. 2020 Oct;
30(22):127589.
PMID: 33007394
Dihydroorotate dehydrogenase (DHODH) enzymatic activity impacts many aspects critical to cell proliferation and survival. Recently, DHODH has been identified as a target for acute myeloid differentiation therapy. In preclinical models...
9.
Working memory load-dependent changes in cortical network connectivity estimated by machine learning
Eryilmaz H, Dowling K, Hughes D, Rodriguez-Thompson A, Tanner A, Huntington C, et al.
Neuroimage
. 2020 May;
217:116895.
PMID: 32360929
Working memory engages multiple distributed brain networks to support goal-directed behavior and higher order cognition. Dysfunction in working memory has been associated with cognitive impairment in neuropsychiatric disorders. It is...