Vijaykumar Karuppiah
Overview
Explore the profile of Vijaykumar Karuppiah including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
22
Citations
342
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Quast N, Abanades B, Guloglu B, Karuppiah V, Harper S, Raybould M, et al.
Commun Biol
. 2025 Mar;
8(1):362.
PMID: 40038394
T-cell receptor (TCR) structures are currently under-utilised in early-stage drug discovery and repertoire-scale informatics. Here, we leverage a large dataset of solved TCR structures from Immunocore to evaluate the current...
2.
Murugesan G, Paterson R, Kulkarni R, Ilkow V, Suckling R, Connolly M, et al.
Nat Commun
. 2024 Nov;
15(1):10126.
PMID: 39578466
The non-polymorphic HLA-E molecule offers opportunities for new universal immunotherapeutic approaches to chronic infectious diseases. Chronic Hepatitis B virus (HBV) infection is driven in part by T cell dysfunction due...
3.
Karuppiah V, Sangani D, Whaley L, Pengelly R, Uluocak P, Carreira R, et al.
Sci Rep
. 2024 Nov;
14(1):26851.
PMID: 39500929
Specificity of a T cell receptor (TCR) is determined by the combination of its interactions to the peptide and human leukocyte antigen (HLA). TCR-based therapeutic molecules have to date targeted...
4.
Chancellor A, Simmons R, Khanolkar R, Nosi V, Beshirova A, Berloffa G, et al.
J Exp Med
. 2023 Jun;
220(9).
PMID: 37382893
Mucosal-associated invariant T (MAIT) cells use canonical semi-invariant T cell receptors (TCR) to recognize microbial riboflavin precursors displayed by the antigen-presenting molecule MR1. The extent of MAIT TCR crossreactivity toward...
5.
Poole A, Karuppiah V, Hartt A, Haidar J, Moureau S, Dobrzycki T, et al.
Nat Commun
. 2022 Sep;
13(1):5333.
PMID: 36088370
Neoantigens derived from somatic mutations are specific to cancer cells and are ideal targets for cancer immunotherapy. KRAS is the most frequently mutated oncogene and drives the pathogenesis of several...
6.
Barber C, Arena De Souza V, Paterson R, Martin-Urdiroz M, Mulakkal N, Srikannathasan V, et al.
Eur J Immunol
. 2022 Feb;
52(4):618-632.
PMID: 35108401
The nonpolymorphic class Ib molecule, HLA-E, primarily presents peptides from HLA class Ia leader peptides, providing an inhibitory signal to NK cells via CD94/NKG2 interactions. Although peptides of pathogenic origin...
7.
Kearsey L, Prandi N, Karuppiah V, Yan C, Leys D, Toogood H, et al.
FEBS J
. 2019 Oct;
287(8):1511-1524.
PMID: 31605668
In the native pathway to therapeutic cannabinoid biosynthesis in Cannabis sativa, the three-step production of a key intermediate, olivetolic acid, is catalysed by the enzymes tetraketide synthase (TKS; linear tetraketide...
8.
Salleh M, Karuppiah V, Snee M, Thistlethwaite A, Levy C, Knight D, et al.
mBio
. 2019 Jun;
10(3).
PMID: 31186316
Natural competence is the term used to describe the uptake of "naked" extracellular DNA by bacteria; it plays a significant role in horizontal genetic exchange. It is associated with type...
9.
Leferink N, Ranaghan K, Karuppiah V, Currin A, van der Kamp M, Mulholland A, et al.
ACS Catal
. 2019 Jun;
8(5):3780-3791.
PMID: 31157124
Monoterpenes (C10 isoprenoids) are a structurally diverse group of natural compounds that are attractive to industry as flavours and fragrances. Monoterpenes are produced from a single linear substrate, geranyl diphosphate,...
10.
Collins R, Karuppiah V, Siebert C, Dajani R, Thistlethwaite A, Derrick J
Sci Rep
. 2018 Sep;
8(1):14022.
PMID: 30232337
Type IV pili are responsible for a diverse range of functions, including twitching motility and cell adhesion. Assembly of the pilus fiber is driven by a cytoplasmic ATPase: it interacts...