Nigel S Scrutton
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Explore the profile of Nigel S Scrutton including associated specialties, affiliations and a list of published articles.
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347
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4660
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Recent Articles
1.
Yu Y, Jeffreys L, Poddar H, Hill A, Johannissen L, Dai F, et al.
FEBS J
. 2024 Dec;
292(3):635-652.
PMID: 39718193
Photoreceptors control cellular processes in response to light. Most photoreceptors sense blue or red light, but the recent discovery of the cobalamin-dependent photoreceptor, CarH, has expanded the wavelength range of...
2.
Hanko E, Robinson C, Bhanot S, Jervis A, Scrutton N
Microb Cell Fact
. 2024 Nov;
23(1):312.
PMID: 39558341
Background: Flavonoids are a structurally diverse group of secondary metabolites, predominantly produced by plants, which include a range of compounds with pharmacological importance. Pinocembrin is a key branch point intermediate...
3.
Tan J, Hu Q, Scrutton N
Microb Cell Fact
. 2024 Oct;
23(1):279.
PMID: 39415159
Background: Achieving cost-competitiveness remains challenging for industrial biomanufacturing. With whole-cell biocatalysis, inefficiency presents when individual cells vary in their production levels. The problem exacerbates when the basis for such production...
4.
Whitehead J, Leferink N, Hay S, Scrutton N
Chembiochem
. 2024 Oct;
26(1):e202400672.
PMID: 39400489
Rubrobacter radiotolerans nerolidol synthase (NerS) and trans-α-bergamotene synthase (BerS) are among the first terpene synthases (TPSs) discovered from thermotolerant bacteria, and, despite sharing the same substrate, make terpenoid products with...
5.
Zhang L, Ye J, Li G, Park H, Luo H, Lin Y, et al.
Metab Eng
. 2024 Jun;
84:95-108.
PMID: 38901556
Microbial instability is a common problem during bio-production based on microbial hosts. Halomonas bluephagenesis has been developed as a chassis for next generation industrial biotechnology (NGIB) under open and unsterile...
6.
Zhang S, Jeffreys L, Poddar H, Yu Y, Liu C, Patel K, et al.
Nat Commun
. 2024 Mar;
15(1):2740.
PMID: 38548733
Photoreceptor proteins utilise chromophores to sense light and trigger a biological response. The discovery that adenosylcobalamin (or coenzyme B) can act as a light-sensing chromophore heralded a new field of...
7.
Hu Q, Sun S, Zhang Z, Liu W, Yi X, He H, et al.
Metab Eng
. 2024 Feb;
82:238-249.
PMID: 38401747
Ectoine, a crucial osmoprotectant for salt adaptation in halophiles, has gained growing interest in cosmetics and medical industries. However, its production remains challenged by stringent fermentation process in model microorganisms...
8.
Park H, He H, Yan X, Liu X, Scrutton N, Chen G
Biotechnol Adv
. 2024 Jan;
71:108320.
PMID: 38272380
Polyhydroxyalkanoates (PHA) have evolved into versatile biopolymers, transcending their origins as mere bioplastics. This extensive review delves into the multifaceted landscape of PHA applications, shedding light on the diverse industries...
9.
Zhang J, Yan X, Park H, Scrutton N, Chen T, Chen G
Curr Opin Biotechnol
. 2024 Jan;
85:103064.
PMID: 38262074
The use of extremophile organisms such as Halomomas spp. can eliminate the need for fermentation sterilization, significantly reducing process costs. Microbial fermentation is considered a pivotal strategy to reduce reliance...
10.
Taylor A, Zhang S, Johannissen L, Sakuma M, Phillips R, Green A, et al.
FEBS J
. 2023 Dec;
291(7):1404-1421.
PMID: 38060334
The photoenzyme protochlorophyllide oxidoreductase (POR) is an important enzyme for understanding biological H-transfer mechanisms. It uses light to catalyse the reduction of protochlorophyllide to chlorophyllide, a key step in chlorophyll...