Vesa M Olkkonen
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Explore the profile of Vesa M Olkkonen including associated specialties, affiliations and a list of published articles.
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164
Citations
4039
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Recent Articles
1.
Polianskyte-Prause Z, Arora A, Taskinen J, Chaurasiya V, Keskitalo S, Tuhkala A, et al.
Biochim Biophys Acta Mol Cell Res
. 2025 Feb;
1872(3):119926.
PMID: 40010513
Lipid transfer proteins regulate the metabolism of phosphoinositides with key roles in cell signaling, membrane and actin dynamics, intracellular trafficking, and diseases. Nir2/PITPNM1 acts as a cellular phosphatidylinositol/phosphatidic acid (PI/PA)...
2.
Nagaraj M, Emmagouni S, Chaurasiya V, Li L, Nguyen V, Keskitalo S, et al.
FEBS Lett
. 2025 Feb;
PMID: 39891560
GOLM1, a Golgi membrane protein, is upregulated in cancers and liver diseases. Analysis of public RNAseq data from healthy human liver suggested that GOLM1 is predominantly expressed in cholangiocytes. Therefore,...
3.
Dadson P, Honka M, Suomi T, Haridas P, Rokka A, Palani S, et al.
Am J Physiol Endocrinol Metab
. 2025 Jan;
328(3):E311-E324.
PMID: 39819027
In this study, we investigated the impact of bariatric surgery on the adipose proteome to better understand the metabolic and cellular mechanisms underlying weight loss following the procedure. A total...
4.
Taskinen J, Holopainen M, Ruhanen H, van der Stoel M, Kakela R, Ikonen E, et al.
BMC Biol
. 2024 Dec;
22(1):292.
PMID: 39695567
Background: Many members of the oxysterol-binding protein-related protein (ORP) family have been characterized in detail over the past decades, but the lipid transport and other functions of ORP7 still remain...
5.
Lluch A, Latorre J, Oliveras-Canellas N, Fernandez-Sanchez A, Moreno-Navarrete J, Castells-Nobau A, et al.
Mol Metab
. 2024 Oct;
90:102040.
PMID: 39362599
Background: Long non-coding RNAs (lncRNAs) can perform tasks of key relevance in fat cells, contributing, when defective, to the burden of obesity and its sequelae. Here, scrutiny of adipose tissue...
6.
Olkkonen V, Ikonen E
Contact (Thousand Oaks)
. 2024 Aug;
7:25152564241273598.
PMID: 39210909
This review discusses how research around the oxysterol-binding protein family has evolved. We briefly summarize how this protein family, designated OSBP-related (ORP) or OSBP-like (OSBPL) proteins, was discovered, how protein...
7.
Li S, Wang Y, van der Stoel M, Zhou X, Madhusudan S, Kanerva K, et al.
Genome Biol
. 2024 Feb;
25(1):58.
PMID: 38409044
Recent developments in auxin-inducible degron (AID) technology have increased its popularity for chemogenetic control of proteolysis. However, generation of human AID cell lines is challenging, especially in human embryonic stem...
8.
Chaurasiya V, Haridas P, Olkkonen V
Biochem Pharmacol
. 2024 Feb;
222:116081.
PMID: 38408682
Adipose tissue (AT) expansion through hyperplasia or hypertrophy requires vascular remodeling that involves angiogenesis. There is quite some evidence that obese white AT (WAT) displays altered vasculature. Some studies suggest...
9.
Olkkonen V, Gylling H
Adv Exp Med Biol
. 2023 Nov;
1440:353-375.
PMID: 38036889
Oxysterols and phytosterols are sterol compounds present at markedly low levels in tissues and serum of healthy individuals. A wealth of evidence suggests that they could be employed as biomarkers...
10.
Pihlstrom S, Richardt S, Maatta K, Pekkinen M, Olkkonen V, Makitie O, et al.
Front Endocrinol (Lausanne)
. 2023 Oct;
14:1224318.
PMID: 37886644
Pathogenic heterozygous variants in cause a rare monogenic form of osteoporosis known as calvarial doughnut lesions with bone fragility (CDL). The clinical presentations of -related bone pathology range from childhood-onset...