Vasulinga T Ravikumar
Overview
Explore the profile of Vasulinga T Ravikumar including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
22
Citations
53
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Taj S, Narayanan S, Meenakshi S, Sanghvi Y, Ross B, Ravikumar V
Nucleosides Nucleotides Nucleic Acids
. 2008 Aug;
27(9):1024-33.
PMID: 18711665
An optimized process to synthesize DMT protected 2 '-O-methoxyethylguanosine is described. A key step involves the enzymatic deamination of a mixture of alkylated products to selectively afford the desired material...
2.
Maity J, Shakya G, Singh S, Ravikumar V, Parmar V, Prasad A
J Org Chem
. 2008 Jun;
73(14):5629-32.
PMID: 18557651
Candida antarctica lipase-B (CAL-B) immobilized on lewatite selectively acylated the primary hydroxyl group of the furanosyl nucleoside in a mixture of 1-(alpha-D-arabinofuranosyl)thymine and 1-(alpha-D-arabinopyranosyl)thymine. This selective biocatalytic acylation of furanosyl...
3.
Ross B, Springer R, Ravikumar V
Nucleosides Nucleotides Nucleic Acids
. 2008 Jan;
27(1):67-9.
PMID: 18188771
An efficient process to synthesize 2,6-diaminopurine riboside in high yield and quality is described. This inexpensive approach was scaled up to multi-hundred kilogram quantities for use in oligonucleotide therapeutics.
4.
Wang Z, Olsen P, Ravikumar V
Nucleosides Nucleotides Nucleic Acids
. 2007 Apr;
26(3):259-69.
PMID: 17454735
A versatile and conformationally preorganized universal linker molecule is reported here for efficient synthesis of phosphorothioate oligonucleotides. With respect to nucleoside loaded support, comparable yield and quality based on ion-pair...
5.
Krishna Kumar R, Olsen P, Ravikumar V
Nucleosides Nucleotides Nucleic Acids
. 2007 Mar;
26(2):181-8.
PMID: 17365796
Phosphorothioate oligonucleotides could be synthesized using a 0.2 M solution of phenylacetyl disulfide (PADS) in a mixture of pyridine and acetonitrile (1:1, v/v) with > 99.9% step-wise efficiency. Unlike most...
6.
Ross B, Han M, Ravikumar V
Nucleosides Nucleotides Nucleic Acids
. 2006 Aug;
25(7):765-70.
PMID: 16898414
An efficient process to synthesize 5'-O-dimethoxytrityl-N4-benzoyl-5-methyl-2'-deoxycytidine in high yield and quality is described. Final benzoylation was improved by developing a method to selectively hydrolyze benzoyl ester impurities. This inexpensive approach...
7.
Wang Z, Siwkowski A, Lima W, Olsen P, Ravikumar V
Bioorg Med Chem
. 2006 Mar;
14(14):5049-60.
PMID: 16563772
Multiple 2'-O-methoxyethyl modified phosphorothioate oligonucleotides of 18-20-mer in length were synthesized at various scales using 4,5-dicyanoimidazole (DCI) as coupling activator. Extensive synthetic, analytical (using ion-pair LC-MS), and in vivo pharmacological,...
8.
Ravikumar V, Andrade M, Carty R, Dan A, Barone S
Bioorg Med Chem Lett
. 2006 Feb;
16(9):2513-7.
PMID: 16481168
Efficient synthesis of phosphorothioate RNA (PS-RNA) is demonstrated by using phenylacetyl disulfide (PADS) in a mixture of pyridine and acetonitrile (1:1, v/v) for 3 min. Sulfurization is achieved with >99.8%...
9.
Kurata C, Bradley K, Gaus H, Luu N, Cedillo I, Ravikumar V, et al.
Bioorg Med Chem Lett
. 2005 Nov;
16(3):607-14.
PMID: 16274991
Phosphorothioate oligonucleotides manufactured by standard phosphoramidite techniques using 2'-deoxyadenosine- or 2'-O-(2-methoxyethyl)-5-methylcytosine-loaded solid supports contain branched impurities consisting of two chains linked through the exocyclic amino group of the 3'-terminal nucleoside...
10.
Prasad A, Kumar V, Maity J, Sanghvi Y, Ravikumar V, Parmar V
Nucleosides Nucleotides Nucleic Acids
. 2005 Oct;
24(5-7):747-51.
PMID: 16248029
Use of benzoyl cyanide (BzCN) for benzoylation of nucleosides has been studied, both in pyridine and in ionic liquid BzCN in 1-methoxyethyl-3-methylimidazolium methanesulfonate as ionic liquid has been found to...