Vasulinga T Ravikumar
Overview
Explore the profile of Vasulinga T Ravikumar including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
22
Citations
53
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
11.
Krishna Kumar R, Ravikumar V
Bioorg Med Chem Lett
. 2005 Jun;
15(14):3426-9.
PMID: 15946845
Removal of 4,4'-dimethoxytrityl (DMT) groups from primary and secondary hydroxyl functionality was investigated. It was observed that deblocking of DMT group from secondary hydroxyl group of molecules attached to solid...
12.
Prasad A, Kumar V, Malhotra S, Ravikumar V, Sanghvi Y, Parmar V
Bioorg Med Chem
. 2005 Jun;
13(14):4467-72.
PMID: 15921912
Benzoyl cyanide in the ionic liquid 1-methoxyethyl-3-methylimidazolium methanesulfonate has been employed as a 'green' alternative and mild reaction condition protocol to conventional pyridine-benzoyl chloride system for efficient and selective benzoylation...
13.
Capaldi D, Gaus H, Carty R, Moore M, Turney B, Decottignies S, et al.
Bioorg Med Chem Lett
. 2004 Aug;
14(18):4683-90.
PMID: 15324888
Incomplete sulfurization during solid-phase synthesis of phosphorothioate oligonucleotides using phosphoramidite chemistry was identified as the cause of formation of two new classes of process-related oligonucleotide impurities containing a DMTr-C-phosphonate (DMTr=4,4'-dimethoxytrityl)...
14.
Ravikumar V, Lima W, Van Sooy K, Turney B
Nucleosides Nucleotides Nucleic Acids
. 2004 Mar;
23(1-2):149-60.
PMID: 15043143
Multiple phosphorothioate oligonucleotides containing a 3'-terminal negative charge were synthesized and characterized. Influence of the added negative charge on activation of duplexes by RNase H was investigated. No additional help...
15.
Ravikumar V, Cole D
Nucleosides Nucleotides Nucleic Acids
. 2003 Oct;
22(5-8):1639-45.
PMID: 14565485
Coupling of 2'-O-methoxyethylsubstituted nucleoside phosphoramidites to 5'-hydroxyl group of a nucleoside or nucleotide on solid support is under stereochemical process control and is independent of scale, concentration, synthesizer, ratio of...
16.
Ravikumar V, Krishna Kumar R, Capaldi D, Cole D
Nucleosides Nucleotides Nucleic Acids
. 2003 Oct;
22(5-8):1421-5.
PMID: 14565433
Detritylation of a 5'-O-DMT-2'-deoxyadenosine moiety attached to solid support under acidic condition leads to depurination during oligonucleotide synthesis. Deprotection followed by reversed phase HPLC purification leads to desired oligonucleotide contaminated...
17.
Ravikumar V, Cole D
Nucleosides Nucleotides Nucleic Acids
. 2003 Oct;
22(5-8):1415-9.
PMID: 14565432
Activation of 2'-O-substituted ribonucleoside phosphoramidites with various activators during solid-supported synthesis of phosphorothioate oligonucleotides was studied. The Rp:Sp diastereomeric composition of resulting phosphorothioate linkage dependent on pKa of activator utilized...
18.
Ravikumar V, Capaldi D, Lima W, Lesnik E, Turney B, Cole D
Bioorg Med Chem
. 2003 Oct;
11(21):4673-9.
PMID: 14527564
A phosphorothioate-linked oligonucleotide bearing a 3'-terminal phosphorothioate monoester has been synthesized and characterized. This oligonucleotide has been identified as a process-related impurity formed during synthesis of ISIS 2302. Biological properties...
19.
Cheruvallath Z, Krishna Kumar R, Rentel C, Cole D, Ravikumar V
Nucleosides Nucleotides Nucleic Acids
. 2003 Jul;
22(4):461-8.
PMID: 12885126
Diethyldithiodicarbonate (DDD), a cheap and easily prepared compound, is found to be a rapid and efficient sulfurizing reagent in solid phase synthesis of phosphorothioate oligodeoxyribonucleotides via the phosphoramidite approach. Product...
20.
Krishna Kumar R, Cole D, Ravikumar V
Nucleosides Nucleotides Nucleic Acids
. 2003 Jul;
22(4):453-60.
PMID: 12885125
A solution of 2-methyl-5-tert-butylthiophenol and triethylamine in acetonitrile efficiently removed the methyl protecting groups from phosphate and phosphorothioate triesters and yielded oligonucleotides of high quality. This inexpensive odorless liquid is...