Daniel C Capaldi
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Explore the profile of Daniel C Capaldi including associated specialties, affiliations and a list of published articles.
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6
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21
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Recent Articles
1.
Rentel C, Wang X, Batt M, Kurata C, Oliver J, Gaus H, et al.
J Org Chem
. 2005 Nov;
70(20):7841-5.
PMID: 16277303
[Chemical reaction: See text] Depurination is an important degradation pathway for antisense phosphorothioate oligonucleotides under conditions of thermal stress. We present evidence showing that depurinated oligonucleotides react with cytosine-containing sequences...
2.
Kurata C, Bradley K, Gaus H, Luu N, Cedillo I, Ravikumar V, et al.
Bioorg Med Chem Lett
. 2005 Nov;
16(3):607-14.
PMID: 16274991
Phosphorothioate oligonucleotides manufactured by standard phosphoramidite techniques using 2'-deoxyadenosine- or 2'-O-(2-methoxyethyl)-5-methylcytosine-loaded solid supports contain branched impurities consisting of two chains linked through the exocyclic amino group of the 3'-terminal nucleoside...
3.
Gaus H, Olsen P, Van Sooy K, Rentel C, Turney B, Walker K, et al.
Bioorg Med Chem Lett
. 2005 Jul;
15(18):4118-24.
PMID: 16002284
Some commercial batches of dichloroacetic acid (DCA) contain traces of chloral (trichloroacetaldehyde). Using such DCA to effect detritylation during solid-phase oligonucleotide synthesis results in the formation of a family of...
4.
Capaldi D, Gaus H, Carty R, Moore M, Turney B, Decottignies S, et al.
Bioorg Med Chem Lett
. 2004 Aug;
14(18):4683-90.
PMID: 15324888
Incomplete sulfurization during solid-phase synthesis of phosphorothioate oligonucleotides using phosphoramidite chemistry was identified as the cause of formation of two new classes of process-related oligonucleotide impurities containing a DMTr-C-phosphonate (DMTr=4,4'-dimethoxytrityl)...
5.
Ravikumar V, Krishna Kumar R, Capaldi D, Cole D
Nucleosides Nucleotides Nucleic Acids
. 2003 Oct;
22(5-8):1421-5.
PMID: 14565433
Detritylation of a 5'-O-DMT-2'-deoxyadenosine moiety attached to solid support under acidic condition leads to depurination during oligonucleotide synthesis. Deprotection followed by reversed phase HPLC purification leads to desired oligonucleotide contaminated...
6.
Ravikumar V, Capaldi D, Lima W, Lesnik E, Turney B, Cole D
Bioorg Med Chem
. 2003 Oct;
11(21):4673-9.
PMID: 14527564
A phosphorothioate-linked oligonucleotide bearing a 3'-terminal phosphorothioate monoester has been synthesized and characterized. This oligonucleotide has been identified as a process-related impurity formed during synthesis of ISIS 2302. Biological properties...