U Helena Danielson
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Explore the profile of U Helena Danielson including associated specialties, affiliations and a list of published articles.
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111
Citations
907
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Recent Articles
1.
FitzGerald E, Rachman M, Cederfelt D, Myers N, Kovryzchenko D, Zhang H, et al.
Bioorg Med Chem
. 2025 Mar;
121:118134.
PMID: 40024141
SMYD3 (SET- and MYND-domain containing protein 3) is an epigenetic enzyme with lysine methyl transferase activity and multiple protein binding partners. It is implicated in cancer development and active site...
2.
Perez-Ropero G, Perez-Rafols A, Martelli T, Danielson U, Buijs J
Biochemistry
. 2024 Oct;
63(21):2816-2829.
PMID: 39397705
The kinetics of the interaction between Musashi-1 (MSI1) and RNA have been characterized using surface plasmon resonance biosensor analysis. Truncated variants of human MSI1 encompassing the two homologous RNA recognition...
3.
Blaazer A, Singh A, Zara L, Boronat P, Bautista L, Irving S, et al.
ChemMedChem
. 2024 Aug;
19(22):e202400417.
PMID: 39193819
In search of new opportunities to develop Trypanosoma brucei phosphodiesterase B1 (TbrPDEB1) inhibitors that have selectivity over the off-target human PDE4 (hPDE4), different stages of a fragment-growing campaign were studied...
4.
Fekry M, Stenberg G, Dobritzsch D, Danielson U
Protein Expr Purif
. 2024 Jul;
222:106542.
PMID: 38969281
Human ZC3H11A is an RNA-binding zinc finger protein involved in mRNA export and required for the efficient growth of human nuclear replicating viruses. Its biochemical properties are largely unknown so...
5.
FitzGerald E, Cederfelt D, Lund B, Myers N, Zhang H, Dobritzsch D, et al.
RSC Med Chem
. 2024 Jun;
15(6):1982-1990.
PMID: 38911161
A 1056-membered fragment library has been screened against SMYD3 using a novel multiplexed experimental design implemented in a grating coupled interferometry (GCI)-based biosensor. SMYD3 is a prospective target for anticancer...
6.
Cederfelt D, Badgujar D, Au Musse A, Lohkamp B, Danielson U, Dobritzsch D
Biomolecules
. 2023 Dec;
13(12).
PMID: 38136634
The activity of β-ureidopropionase, which catalyses the last step in the degradation of uracil, thymine, and analogous antimetabolites, is cooperatively regulated by the substrate and product of the reaction. This...
7.
Fekry M, Dave K, Badgujar D, Hamnevik E, Aurelius O, Dobritzsch D, et al.
Biomolecules
. 2023 Sep;
13(9).
PMID: 37759761
Tyrosinases belong to the type-III copper enzyme family, which is involved in melanin production in a wide range of organisms. Despite similar overall characteristics and functions, their structures, activities, substrate...
8.
FitzGerald E, Vagrys D, Opassi G, Klein H, Hamilton D, Talibov V, et al.
SLAS Discov
. 2023 Sep;
29(1):40-51.
PMID: 37714432
Surface plasmon resonance (SPR) biosensor methods are ideally suited for fragment-based lead discovery. However, generally applicable experimental procedures and detailed protocols are lacking, especially for structurally or physico-chemically challenging targets...
9.
Al-Amin R, Johansson L, Abdurakhmanov E, Landegren N, Lof L, Arngarden L, et al.
Nucleic Acids Res
. 2022 Oct;
50(22):e129.
PMID: 36189884
Drugs are designed to bind their target proteins in physiologically relevant tissues and organs to modulate biological functions and elicit desirable clinical outcomes. Information about target engagement at cellular and...
10.
Parenti M, Naldi M, Manoni E, Fabini E, Cederfelt D, Talibov V, et al.
Eur J Med Chem
. 2022 Sep;
243:114683.
PMID: 36116234
Recent findings support the hypothesis that inhibition of SMYD3 methyltransferase may be a therapeutic avenue for some of the deadliest cancer types. Herein, active site-selective covalent SMYD3 inhibitors were designed...