Doreen Dobritzsch
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Explore the profile of Doreen Dobritzsch including associated specialties, affiliations and a list of published articles.
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62
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786
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Recent Articles
1.
Fekry M, Stenberg G, Dobritzsch D, Danielson U
Protein Expr Purif
. 2024 Jul;
222:106542.
PMID: 38969281
Human ZC3H11A is an RNA-binding zinc finger protein involved in mRNA export and required for the efficient growth of human nuclear replicating viruses. Its biochemical properties are largely unknown so...
2.
FitzGerald E, Cederfelt D, Lund B, Myers N, Zhang H, Dobritzsch D, et al.
RSC Med Chem
. 2024 Jun;
15(6):1982-1990.
PMID: 38911161
A 1056-membered fragment library has been screened against SMYD3 using a novel multiplexed experimental design implemented in a grating coupled interferometry (GCI)-based biosensor. SMYD3 is a prospective target for anticancer...
3.
van Kuilenburg A, Pleunis-van Empel M, Brouwer R, Sijben A, Knapen D, Oude Munnink T, et al.
JCO Precis Oncol
. 2024 May;
8:e2300599.
PMID: 38709992
A DPD deficiency should be considered in case of severe toxicity even in the absence of common risk variants in DPYD.
4.
van Karnebeek C, Tarailo-Graovac M, Leen R, Meinsma R, Correard S, Jansen-Meijer J, et al.
Genet Med
. 2024 Feb;
26(6):101104.
PMID: 38411040
Purpose: The functionality of many cellular proteins depends on cofactors; yet, they have only been implicated in a minority of Mendelian diseases. Here, we describe the first 2 inherited disorders...
5.
Cederfelt D, Badgujar D, Au Musse A, Lohkamp B, Danielson U, Dobritzsch D
Biomolecules
. 2023 Dec;
13(12).
PMID: 38136634
The activity of β-ureidopropionase, which catalyses the last step in the degradation of uracil, thymine, and analogous antimetabolites, is cooperatively regulated by the substrate and product of the reaction. This...
6.
Fekry M, Dave K, Badgujar D, Hamnevik E, Aurelius O, Dobritzsch D, et al.
Biomolecules
. 2023 Sep;
13(9).
PMID: 37759761
Tyrosinases belong to the type-III copper enzyme family, which is involved in melanin production in a wide range of organisms. Despite similar overall characteristics and functions, their structures, activities, substrate...
7.
Kliche J, Garvanska D, Simonetti L, Badgujar D, Dobritzsch D, Nilsson J, et al.
Mol Syst Biol
. 2023 May;
19(7):e11164.
PMID: 37219487
Phosphorylation is a ubiquitous post-translation modification that regulates protein function by promoting, inhibiting or modulating protein-protein interactions. Hundreds of thousands of phosphosites have been identified but the vast majority have...
8.
Mihalic F, Simonetti L, Giudice G, Rubin Sander M, Lindqvist R, Peters M, et al.
Nat Commun
. 2023 Apr;
14(1):2409.
PMID: 37100772
Viruses mimic host short linear motifs (SLiMs) to hijack and deregulate cellular functions. Studies of motif-mediated interactions therefore provide insight into virus-host dependencies, and reveal targets for therapeutic intervention. Here,...
9.
FitzGerald E, Butko M, Boronat P, Cederfelt D, Abramsson M, Ludviksdottir H, et al.
RSC Adv
. 2022 Apr;
11(13):7527-7537.
PMID: 35423271
Biophysical screening of compound libraries for the identification of ligands that interact with a protein is efficient, but does typically not reveal if (or how) ligands may interfere with its...
10.
Dobritzsch D, Meijer J, Meinsma R, Maurer D, Monavari A, Gummesson A, et al.
Mol Genet Metab
. 2022 Feb;
136(3):177-185.
PMID: 35151535
β-Ureidopropionase is the third enzyme of the pyrimidine degradation pathway and catalyses the conversion of N-carbamyl-β-alanine and N-carbamyl-β-aminoisobutyric acid to β-alanine and β-aminoisobutyric acid, ammonia and CO. To date, only...