Toby N Trahair
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Explore the profile of Toby N Trahair including associated specialties, affiliations and a list of published articles.
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49
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755
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Recent Articles
1.
Connerty P, Xie J, El-Najjar F, Trahair T, Jayatilleke N, Mayoh C, et al.
Br J Haematol
. 2025 Feb;
PMID: 39984432
Acute myeloid leukaemia (AML) remains a deadly disease, largely due to the persistence of drug-resistant leukaemia-initiating cells (LICs) which promote relapse. Therefore, effective therapies must target LICs. Patient-derived xenografts (PDXs)...
2.
Copper chelation redirects neutrophil function to enhance anti-GD2 antibody therapy in neuroblastoma
Rouaen J, Salerno A, Shai-Hee T, Murray J, Castrogiovanni G, McHenry C, et al.
Nat Commun
. 2024 Dec;
15(1):10462.
PMID: 39668192
Anti-disialoganglioside (GD2) antibody therapy has provided clinical benefit to patients with neuroblastoma however efficacy is likely impaired by the immunosuppressive tumor microenvironment. We have previously defined a link between intratumoral...
3.
Chen D, Sutton R, Giles J, Venn N, Huang L, Law T, et al.
Clin Chem
. 2024 Nov;
67(10):1373-1383.
PMID: 39506256
Background: Droplet digital PCR (ddPCR) is a promising technique for absolute quantification of minimal residual disease (MRD) in acute lymphoblastic leukemia (ALL), but there is no comprehensive quality assurance program...
4.
Toscan C, McCalmont H, Ashoorzadeh A, Lin X, Fu Z, Doculara L, et al.
Blood Cancer J
. 2024 Nov;
14(1):192.
PMID: 39505850
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy that expresses high levels of the enzyme aldo-keto reductase family 1 member C3 (AKR1C3). To exploit this finding, we developed...
5.
Hovorkova L, Winkowska L, Skorepova J, Krumbholz M, Benesova A, Polivkova V, et al.
Mol Cancer
. 2024 Jul;
23(1):138.
PMID: 38970095
Background: The BCR::ABL1 is a hallmark of chronic myeloid leukemia (CML) and is also found in acute lymphoblastic leukemia (ALL). Most genomic breaks on the BCR side occur in two...
6.
Lau L, Khuong-Quang D, Mayoh C, Wong M, Barahona P, Ajuyah P, et al.
Nat Med
. 2024 Jun;
30(7):1913-1922.
PMID: 38844796
Recent research showed that precision medicine can identify new treatment strategies for patients with childhood cancers. However, it is unclear which patients will benefit most from precision-guided treatment (PGT). Here...
7.
Schilstra C, Sansom-Daly U, Ellis S, Anazodo A, Trahair T, Lindsay T, et al.
J Adolesc Young Adult Oncol
. 2024 Apr;
13(4):674-682.
PMID: 38597951
Social anxiety disorder (SAD) remains an understudied potential link between the cancer experience and adolescent and young adult (AYA) cancer survivors' poor psychosocial outcomes. We investigated the frequency and duration...
8.
Mayoh C, Mao J, Xie J, Tax G, Chow S, Cadiz R, et al.
Cancer Res
. 2023 Jul;
83(16):2716-2732.
PMID: 37523146
Significance: Integrating HTS with molecular profiling is a powerful tool for expanding precision medicine to support drug treatment recommendations and broaden the therapeutic options available to high-risk pediatric cancers.
9.
Daly R, Hetherington K, Hazell E, Wadling B, Tyrrell V, Tucker K, et al.
J Pers Med
. 2023 Jul;
13(7).
PMID: 37511646
Precision medicine programs aim to utilize novel technologies to identify personalized treatments for children with cancer. Delivering these programs requires interdisciplinary efforts, yet the many groups involved are understudied. This...
10.
Schilstra C, Sansom-Daly U, Ellis S, Trahair T, Anazodo A, Amiruddin A, et al.
J Adolesc Young Adult Oncol
. 2023 Jun;
13(1):8-29.
PMID: 37367208
More than 1000 Australian adolescents and young adults (AYAs) are diagnosed with cancer annually. Many report unmet social well-being needs, which impact their mental health. Australian AYA cancer care providers...