Toby N Trahair
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Explore the profile of Toby N Trahair including associated specialties, affiliations and a list of published articles.
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49
Citations
755
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Recent Articles
11.
Hastings J, Latham S, Kamili A, Wheatley M, Han J, Wong-Erasmus M, et al.
Sci Adv
. 2023 Mar;
9(9):eabp8314.
PMID: 36867694
Gene expression noise is known to promote stochastic drug resistance through the elevated expression of individual genes in rare cancer cells. However, we now demonstrate that chemoresistant neuroblastoma cells emerge...
12.
Schilstra C, McCleary K, Fardell J, Donoghoe M, McCormack E, Kotecha R, et al.
BMC Cancer
. 2022 Sep;
22(1):985.
PMID: 36109702
Background: Pediatric acute lymphoblastic leukemia (ALL) therapy is accompanied by treatment-related toxicities (TRTs) and impaired quality of life. In Australia and New Zealand, children with ALL are treated with either...
13.
Pearson H, Hunt K, Trahair T, Lock R, Lee H, de Bock C
Hemasphere
. 2022 Jun;
6(6):e734.
PMID: 35651714
Drug resistance and treatment failure in pediatric acute lymphoblastic leukemia (ALL) are in part driven by tumor heterogeneity and clonal evolution. Although bulk tumor genomic analyses have provided some insight...
14.
Venn N, Huang L, Hovorkova L, Muskovic W, Wong M, Law T, et al.
Br J Cancer
. 2022 Jun;
127(5):908-915.
PMID: 35650277
Background: ABL-class fusions including NUP214-ABL1 and EBF1-PDGFRB occur in high risk acute lymphoblastic leukaemia (ALL) with gene expression patterns similar to BCR-ABL-positive ALL. Our aim was to evaluate new DNA-based...
15.
Doculara L, Trahair T, Bayat N, Lock R
Front Mol Biosci
. 2022 Jun;
9:885597.
PMID: 35647029
The measurement of circulating tumor DNA (ctDNA) has gained increasing prominence as a minimally invasive tool for the detection of cancer-specific markers in plasma. In adult cancers, ctDNA detection has...
16.
Mesbahi Y, Trahair T, Lock R, Connerty P
Front Oncol
. 2022 Feb;
12:807266.
PMID: 35223487
Despite intensive chemotherapy regimens, up to 60% of adults with acute myeloid leukaemia (AML) will relapse and eventually succumb to their disease. Recent studies suggest that leukaemic stem cells (LSCs)...
17.
In vitro and in vivo drug screens of tumor cells identify novel therapies for high-risk child cancer
Lau L, Mayoh C, Xie J, Barahona P, Mackenzie K, Wong M, et al.
EMBO Mol Med
. 2021 Dec;
14(4):e14608.
PMID: 34927798
Biomarkers which better match anticancer drugs with cancer driver genes hold the promise of improved clinical responses and cure rates. We developed a precision medicine platform of rapid high-throughput drug...
18.
Subhash V, Huang L, Kamili A, Wong M, Chen D, Venn N, et al.
Br J Cancer
. 2021 Sep;
126(3):482-491.
PMID: 34471258
Background: Minimal residual disease (MRD) measurement is a cornerstone of contemporary acute lymphoblastic leukaemia (ALL) treatment. The presence of immunoglobulin (Ig) and T cell receptor (TCR) gene recombinations in leukaemic...
19.
Schilstra C, Sansom-Daly U, Schaffer M, Fardell J, Anazodo A, McCowage G, et al.
J Adolesc Young Adult Oncol
. 2021 Jul;
11(2):211-222.
PMID: 34297633
Involvement of adolescent and young adult (AYAs) cancer survivors as consumers in research is increasingly encouraged, yet few studies have identified the feasibility and acceptability of methods used to involve...
20.
Schilstra C, Fardell J, Ellis S, Jones K, Anazodo A, Trahair T, et al.
J Adolesc Young Adult Oncol
. 2021 Jul;
11(2):129-137.
PMID: 34252287
Adolescent and young adult (AYA) cancer survivors may be at risk of developing symptoms of social anxiety disorder (SAD) due to disruptions in social participation and functioning following a cancer...