Jamie I Fletcher
Overview
Explore the profile of Jamie I Fletcher including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
52
Citations
3947
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Murray J, Valli E, Milazzo G, Mayoh C, Gifford A, Fletcher J, et al.
Nat Commun
. 2024 Jul;
15(1):5585.
PMID: 38992040
MYCN oncogene amplification is frequently observed in aggressive childhood neuroblastoma. Using an unbiased large-scale mutagenesis screen in neuroblastoma-prone transgenic mice, we identify a single germline point mutation in the transcriptional...
2.
Hanssen K, Fletcher J, Kamili A
Methods Mol Biol
. 2024 Apr;
2806:55-74.
PMID: 38676796
Realistic and renewable laboratory models that accurately reflect the distinct clinical features of childhood cancers have enormous potential to speed research progress. These models help us to understand disease biology,...
3.
Nelson C, Rogers S, Roychoudhury K, Sing Tan Y, Atkinson C, Sobinoff A, et al.
Nat Commun
. 2024 Feb;
15(1):1385.
PMID: 38360978
The Eyes Absent proteins (EYA1-4) are a biochemically unique group of tyrosine phosphatases known to be tumour-promoting across a range of cancer types. To date, the targets of EYA phosphatase...
4.
Mayoh C, Mao J, Xie J, Tax G, Chow S, Cadiz R, et al.
Cancer Res
. 2023 Jul;
83(16):2716-2732.
PMID: 37523146
Significance: Integrating HTS with molecular profiling is a powerful tool for expanding precision medicine to support drug treatment recommendations and broaden the therapeutic options available to high-risk pediatric cancers.
5.
Sun C, Daniel P, Bradshaw G, Shi H, Loi M, Chew N, et al.
Cancer Cell
. 2023 Mar;
41(4):660-677.e7.
PMID: 37001527
Pediatric solid and central nervous system tumors are the leading cause of cancer-related death among children. Identifying new targeted therapies necessitates the use of pediatric cancer models that faithfully recapitulate...
6.
Hastings J, Latham S, Kamili A, Wheatley M, Han J, Wong-Erasmus M, et al.
Sci Adv
. 2023 Mar;
9(9):eabp8314.
PMID: 36867694
Gene expression noise is known to promote stochastic drug resistance through the elevated expression of individual genes in rare cancer cells. However, we now demonstrate that chemoresistant neuroblastoma cells emerge...
7.
Seneviratne J, Carter D, Mittra R, Gifford A, Kim P, Luo J, et al.
Int J Cancer
. 2022 Nov;
152(7):1399-1413.
PMID: 36346110
The mitochondrion is a gatekeeper of apoptotic processes, and mediates drug resistance to several chemotherapy agents used to treat cancer. Neuroblastoma is a common solid cancer in young children with...
8.
Rosser S, Atkinson C, Nath C, Fletcher J
J Sep Sci
. 2022 May;
45(14):2508-2519.
PMID: 35567751
A liquid chromatography-tandem mass spectrometry method was developed and validated for the simultaneous quantification of vincristine and tariquidar in 10 μL of mouse whole blood using volumetric absorptive microsampling devices....
9.
Hanssen K, Wheatley M, Yu D, Conseil G, Norris M, Haber M, et al.
FEBS J
. 2022 Jan;
289(13):3854-3875.
PMID: 35080351
MRP1 (ABCC1) is a membrane transporter that confers multidrug resistance in cancer cells by exporting chemotherapeutic agents, often in a reduced glutathione (GSH)-dependent manner. This transport activity can be altered...
10.
Hanssen K, Haber M, Fletcher J
Drug Resist Updat
. 2022 Jan;
59:100795.
PMID: 34983733
Resistance to chemotherapy remains one of the most significant obstacles to successful cancer treatment. While inhibiting drug efflux mediated by ATP-binding cassette (ABC) transporters is a seemingly attractive and logical...