Tobias Karlberg
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Explore the profile of Tobias Karlberg including associated specialties, affiliations and a list of published articles.
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43
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1821
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Recent Articles
11.
Ekblad T, Lindgren A, Andersson C, Caraballo R, Thorsell A, Karlberg T, et al.
Eur J Med Chem
. 2015 Apr;
95:546-51.
PMID: 25847771
Protein ADP-ribosylation is a post-translational modification involved in DNA repair, protein degradation, transcription regulation, and epigenetic events. Intracellular ADP-ribosylation is catalyzed predominantly by ADP-ribosyltransferases with diphtheria toxin homology (ARTDs). The...
12.
Karlberg T, Klepsch M, Thorsell A, Andersson C, Linusson A, Schuler H
J Biol Chem
. 2015 Jan;
290(12):7336-44.
PMID: 25635049
The mammalian poly(ADP-ribose) polymerase (PARP) family includes ADP-ribosyltransferases with diphtheria toxin homology (ARTD). Most members have mono-ADP-ribosyltransferase activity. PARP13/ARTD13, also called zinc finger antiviral protein, has roles in viral immunity...
13.
Liscio P, Carotti A, Asciutti S, Karlberg T, Bellocchi D, Llacuna L, et al.
J Med Chem
. 2014 Feb;
57(6):2807-12.
PMID: 24527792
Searching for selective tankyrases (TNKSs) inhibitors, a new small series of 6,8-disubstituted triazolo[4,3-b]piridazines has been synthesized and characterized biologically. Structure-based optimization of the starting hit compound NNL (3) prompted us...
14.
Lindgren A, Karlberg T, Ekblad T, Spjut S, Thorsell A, Andersson C, et al.
J Med Chem
. 2013 Nov;
56(23):9556-68.
PMID: 24188023
The racemic 3-(4-oxo-3,4-dihydroquinazolin-2-yl)-N-[1-(pyridin-2-yl)ethyl]propanamide, 1, has previously been identified as a potent but unselective inhibitor of diphtheria toxin-like ADP-ribosyltransferase 3 (ARTD3). Herein we describe synthesis and evaluation of 55 compounds in...
15.
Lindgren A, Karlberg T, Thorsell A, Hesse M, Spjut S, Ekblad T, et al.
ACS Chem Biol
. 2013 Jun;
8(8):1698-703.
PMID: 23742272
Inhibiting ADP-ribosyl transferases with PARP-inhibitors is considered a promising strategy for the treatment of many cancers and ischemia, but most of the cellular targets are poorly characterized. Here, we describe...
16.
Forst A, Karlberg T, Herzog N, Thorsell A, Gross A, Feijs K, et al.
Structure
. 2013 Mar;
21(3):462-75.
PMID: 23473667
ADP-ribosyltransferases (ARTs) catalyze the transfer of ADP-ribose from NAD(+) onto substrates. Some ARTs generate in an iterative process ADP-ribose polymers that serve as adaptors for distinct protein domains. Other ARTs,...
17.
Karlberg T, Langelier M, Pascal J, Schuler H
Mol Aspects Med
. 2013 Mar;
34(6):1088-108.
PMID: 23458732
ADP-ribosylation of proteins regulates protein activities in various processes including transcription control, chromatin organization, organelle assembly, protein degradation, and DNA repair. Modulating the proteins involved in the metabolism of ADP-ribosylation...
18.
Andersson C, Karlberg T, Ekblad T, Lindgren A, Thorsell A, Spjut S, et al.
J Med Chem
. 2012 Jul;
55(17):7706-18.
PMID: 22823910
The diphtheria toxin-like ADP-ribosyltransferases (ARTDs) are an enzyme family that catalyzes the transfer of ADP-ribose units onto substrate proteins by using nicotinamide adenine dinucleotide (NAD(+)) as a cosubstrate. They have...
19.
Karlberg T, Thorsell A, Kallas A, Schuler H
J Biol Chem
. 2012 Jun;
287(29):24077-81.
PMID: 22661712
ADP-ribosylation is involved in the regulation of DNA repair, transcription, and other processes. The 18 human ADP-ribose transferases with diphtheria toxin homology include ARTD1/PARP1, a cancer drug target. Knowledge of...
20.
Thangavelu K, Pan C, Karlberg T, Balaji G, Uttamchandani M, Suresh V, et al.
Proc Natl Acad Sci U S A
. 2012 Apr;
109(20):7705-10.
PMID: 22538822
Besides thriving on altered glucose metabolism, cancer cells undergo glutaminolysis to meet their energy demands. As the first enzyme in catalyzing glutaminolysis, human kidney-type glutaminase isoform (KGA) is becoming an...