Structural Biology of the Writers, Readers, and Erasers in Mono- and Poly(ADP-ribose) Mediated Signaling

Overview

Journal Mol Aspects Med

Specialties Biochemistry
Molecular Biology

Date 2013 Mar 6

PMID 23458732

Citations 29

Authors

Tobias Karlberg

Marie-France Langelier

John M Pascal

Herwig Schuler

Affiliations

Soon will be listed here.

Abstract

ADP-ribosylation of proteins regulates protein activities in various processes including transcription control, chromatin organization, organelle assembly, protein degradation, and DNA repair. Modulating the proteins involved in the metabolism of ADP-ribosylation can have therapeutic benefits in various disease states. Protein crystal structures can help understand the biological functions, facilitate detailed analysis of single residues, as well as provide a basis for development of small molecule effectors. Here we review recent advances in our understanding of the structural biology of the writers, readers, and erasers of ADP-ribosylation.

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