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Timothy P Fleming

Explore the profile of Timothy P Fleming including associated specialties, affiliations and a list of published articles. Areas
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Articles 40
Citations 1116
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Recent Articles
1.
Zhang X, Goedegebuure S, Chen M, Mishra R, Zhang F, Yu Y, et al.
Genome Med . 2024 Nov; 16(1):131. PMID: 39538331
Background: Neoantigen vaccines can induce or enhance highly specific antitumor immune responses with minimal risk of autoimmunity. We have developed a neoantigen DNA vaccine platform capable of efficiently presenting both...
2.
Guerrero-Alba A, Bansal S, Sankpal A, Mitra G, Rahman M, Ravichandran R, et al.
Front Mol Biosci . 2024 Aug; 11:1365783. PMID: 39211743
In the realm of biomedical advancement, extracellular vesicles (EVs) are revolutionizing our capacity to diagnose, monitor, and predict disease progression. However, the comprehensive exploration and clinical application of EVs face...
3.
Omar F, Brown T, Gillanders W, Fleming T, Smith M, Bremner R, et al.
PLoS One . 2023 May; 18(5):e0285707. PMID: 37192201
Next generation sequencing of human cancer mutations has identified novel therapeutic targets. Activating Ras oncogene mutations play a central role in oncogenesis, and Ras-driven tumorigenesis upregulates an array of genes...
4.
Lee J, Chen R, Mohanakumar T, Bremner R, Mittal S, Fleming T
Onco Targets Ther . 2021 Jun; 14:3813-3820. PMID: 34188489
Introduction: Esophageal cancer (EC) is an aggressive cancer type that is increasing at a high rate in the US and worldwide. Extensive sequencing of EC specimens has shown that there...
5.
Sankpal N, Brown T, Fleming T, Herndon J, Amaravati A, Loynd A, et al.
BMC Cancer . 2021 May; 21(1):541. PMID: 33980181
Background: EpCAM (Epithelial cell adhesion molecule) is often dysregulated in epithelial cancers. Prior studies implicate EpCAM in the regulation of oncogenic signaling pathways and epithelial-to-mesenchymal transition. It was recently demonstrated...
6.
Li L, Zhang X, Wang X, Kim S, Herndon J, Becker-Hapak M, et al.
Genome Med . 2021 Apr; 13(1):56. PMID: 33879241
Background: Preclinical studies and early clinical trials have shown that targeting cancer neoantigens is a promising approach towards the development of personalized cancer immunotherapies. DNA vaccines can be rapidly and...
7.
Sharma P, Dmitriev I, Kashentseva E, Raes G, Li L, Kim S, et al.
Cancer Gene Ther . 2017 Dec; 25(1-2):27-38. PMID: 29242639
Adenoviral (Ad) vector vaccines represent one of the most promising modern vaccine platforms, and Ad vector vaccines are currently being investigated in human clinical trials for infectious disease and cancer....
8.
Zhang X, Kim S, Hundal J, Herndon J, Li S, Petti A, et al.
Cancer Immunol Res . 2017 Jun; 5(7):516-523. PMID: 28619968
Next-generation sequencing technologies have provided insights into the biology and mutational landscape of cancer. Here, we evaluate the relevance of cancer neoantigens in human breast cancers. Using patient-derived xenografts from...
9.
Li L, Goedegebuure S, Fleming T, Gillanders W
Immunotherapy . 2015 Aug; 7(7):709-11. PMID: 26250406
No abstract available.
10.
Hoekman E, Smit V, Fleming T, Louwe L, Fleuren G, Hilders C
Fertil Steril . 2014 Dec; 103(2):469-77. PMID: 25497447
Objective: To exclude minimal residual disease in remaining ovarian tissue after harvesting the ovarian cortex for cryopreservation, by means of a tailor-made approach. Design: Retrospective case series. Setting: Hospital laboratory....