John M Herndon
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Explore the profile of John M Herndon including associated specialties, affiliations and a list of published articles.
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28
Citations
1950
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Recent Articles
1.
Mo C, Liu J, Chen S, Storrs E, Targino da Costa A, Houston A, et al.
Nature
. 2024 Oct;
634(8036):1178-1186.
PMID: 39478210
To study the spatial interactions among cancer and non-cancer cells, we here examined a cohort of 131 tumour sections from 78 cases across 6 cancer types by Visium spatial transcriptomics...
2.
Iglesia M, Jayasinghe R, Chen S, Terekhanova N, Herndon J, Storrs E, et al.
Nat Cancer
. 2024 Oct;
5(11):1713-1736.
PMID: 39478117
Breast cancer (BC) is defined by distinct molecular subtypes with different cells of origin. The transcriptional networks that characterize the subtype-specific tumor-normal lineages are not established. In this work, we...
3.
Wu Y, Chen S, Yang X, Sato K, Lal P, Wang Y, et al.
Cancer Res
. 2023 Dec;
83(24):4161-4178.
PMID: 38098449
Significance: The molecular-guided therapeutic strategy of combining cabozantinib and sapanisertib restrains ERK activity to effectively suppress growth of renal cell carcinomas, including those unresponsive to immune checkpoint inhibitors.
4.
Iglesia M, Jayasinghe R, Chen S, Terekhanova N, Herndon J, Storrs E, et al.
bioRxiv
. 2023 Nov;
PMID: 37961519
Breast cancer is a heterogeneous disease, and treatment is guided by biomarker profiles representing distinct molecular subtypes. Breast cancer arises from the breast ductal epithelium, and experimental data suggests breast...
5.
Terekhanova N, Karpova A, Liang W, Strzalkowski A, Chen S, Li Y, et al.
Nature
. 2023 Nov;
623(7986):432-441.
PMID: 37914932
Chromatin accessibility is essential in regulating gene expression and cellular identity, and alterations in accessibility have been implicated in driving cancer initiation, progression and metastasis. Although the genetic contributions to...
6.
Ademuyiwa F, Gao F, Street C, Chen I, Northfelt D, Wesolowski R, et al.
NPJ Breast Cancer
. 2022 Dec;
8(1):134.
PMID: 36585404
Atezolizumab with chemotherapy has shown improved progression-free and overall survival in patients with metastatic PD-L1 positive triple negative breast cancer (TNBC). Atezolizumab with anthracycline- and taxane-based neoadjuvant chemotherapy has also...
7.
Lander V, Belle J, Kingston N, Herndon J, Hogg G, Liu X, et al.
Cancer Discov
. 2022 Sep;
12(12):2774-2799.
PMID: 36165893
Significance: Checkpoint immunotherapeutics have not been effective in PDAC, even when combined with RT. One possible explanation is that RT fails to prime T-cell responses in PDAC. Here, we show...
8.
Zhou D, Jayasinghe R, Chen S, Herndon J, Iglesia M, Navale P, et al.
Nat Genet
. 2022 Aug;
54(9):1390-1405.
PMID: 35995947
Pancreatic ductal adenocarcinoma is a lethal disease with limited treatment options and poor survival. We studied 83 spatial samples from 31 patients (11 treatment-naïve and 20 treated) using single-cell/nucleus RNA...
9.
Storrs E, Zhou D, Wendl M, Wyczalkowski M, Karpova A, Wang L, et al.
Bioinform Adv
. 2022 May;
2(1):vbac028.
PMID: 35603231
Motivation: The use of single-cell methods is expanding at an ever-increasing rate. While there are established algorithms that address cell classification, they are limited in terms of cross platform compatibility,...
10.
Schapiro D, Yapp C, Sokolov A, Reynolds S, Chen Y, Sudar D, et al.
Nat Methods
. 2022 Mar;
19(3):262-267.
PMID: 35277708
No abstract available.