William E Gillanders
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Explore the profile of William E Gillanders including associated specialties, affiliations and a list of published articles.
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136
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4932
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Recent Articles
1.
Xia H, Hoang M, Schmidt E, Kiwala S, McMichael J, Skidmore Z, et al.
Genome Med
. 2024 Nov;
16(1):132.
PMID: 39538339
Background: Neoantigen-targeting therapies including personalized vaccines have shown promise in the treatment of cancers, particularly when used in combination with checkpoint blockade therapy. At least 100 clinical trials involving these...
2.
Zhang X, Goedegebuure S, Chen M, Mishra R, Zhang F, Yu Y, et al.
Genome Med
. 2024 Nov;
16(1):131.
PMID: 39538331
Background: Neoantigen vaccines can induce or enhance highly specific antitumor immune responses with minimal risk of autoimmunity. We have developed a neoantigen DNA vaccine platform capable of efficiently presenting both...
3.
Mo C, Liu J, Chen S, Storrs E, Targino da Costa A, Houston A, et al.
Nature
. 2024 Oct;
634(8036):1178-1186.
PMID: 39478210
To study the spatial interactions among cancer and non-cancer cells, we here examined a cohort of 131 tumour sections from 78 cases across 6 cancer types by Visium spatial transcriptomics...
4.
Iglesia M, Jayasinghe R, Chen S, Terekhanova N, Herndon J, Storrs E, et al.
Nat Cancer
. 2024 Oct;
5(11):1713-1736.
PMID: 39478117
Breast cancer (BC) is defined by distinct molecular subtypes with different cells of origin. The transcriptional networks that characterize the subtype-specific tumor-normal lineages are not established. In this work, we...
5.
Xia H, Hoang M, Schmidt E, Kiwala S, McMichael J, Skidmore Z, et al.
ArXiv
. 2024 Jul;
PMID: 38947921
Background: Neoantigen targeting therapies including personalized vaccines have shown promise in the treatment of cancers, particularly when used in combination with checkpoint blockade therapy. At least 100 clinical trials involving...
6.
Chen M, Zhang F, Goedegebuure S, Gillanders W
Front Immunol
. 2024 Jun;
15:1393451.
PMID: 38903502
Dendritic cells (DCs) play a central role in the orchestration of effective T cell responses against tumors. However, their functional behavior is context-dependent. DC type, transcriptional program, location, intratumoral factors,...
7.
Transcription factor C/EBPα is required for the development of Ly6C monocytes but not Ly6C monocytes
Kim S, Chen J, Ou F, Liu T, Jo S, Gillanders W, et al.
Proc Natl Acad Sci U S A
. 2024 Apr;
121(15):e2315659121.
PMID: 38564635
Monocytes comprise two major subsets, Ly6C classical monocytes and Ly6C nonclassical monocytes. Notch2 signaling in Ly6C monocytes triggers transition to Ly6C monocytes, which require , , , and . By...
8.
Geng K, Rice-Boucher P, Kashentseva E, Dmitriev I, Lu Z, Goedegebuure S, et al.
Viruses
. 2023 Nov;
15(11).
PMID: 38005953
mRNA vaccines have attracted widespread research attention with clear advantages in terms of molecular flexibility, rapid development, and potential for personalization. However, current mRNA vaccine platforms have not been optimized...
9.
Iglesia M, Jayasinghe R, Chen S, Terekhanova N, Herndon J, Storrs E, et al.
bioRxiv
. 2023 Nov;
PMID: 37961519
Breast cancer is a heterogeneous disease, and treatment is guided by biomarker profiles representing distinct molecular subtypes. Breast cancer arises from the breast ductal epithelium, and experimental data suggests breast...
10.
Ladner D, Goldstein A, Billiar T, Cameron A, Carpizo D, Chu D, et al.
Ann Surg
. 2023 Nov;
279(2):231-239.
PMID: 37916404
Objective: To create a blueprint for surgical department leaders, academic institutions, and funding agencies to optimally support surgeon-scientists. Background: Scientific contributions by surgeons have been transformative across many medical disciplines....