Timothy L Tickle
Overview
Explore the profile of Timothy L Tickle including associated specialties, affiliations and a list of published articles.
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27
Citations
6085
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Recent Articles
1.
Guo M, Morley M, Jiang C, Wu Y, Li G, Du Y, et al.
Nat Commun
. 2023 Jul;
14(1):4566.
PMID: 37516747
Accurate cell type identification is a key and rate-limiting step in single-cell data analysis. Single-cell references with comprehensive cell types, reproducible and functionally validated cell identities, and common nomenclatures are...
2.
Ament S, Adkins R, Carter R, Chrysostomou E, Colantuoni C, Crabtree J, et al.
Nucleic Acids Res
. 2022 Nov;
51(D1):D1075-D1085.
PMID: 36318260
Scalable technologies to sequence the transcriptomes and epigenomes of single cells are transforming our understanding of cell types and cell states. The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative...
3.
Rehm H, Page A, Smith L, Adams J, Alterovitz G, Babb L, et al.
Cell Genom
. 2022 Jan;
1(2).
PMID: 35072136
The Global Alliance for Genomics and Health (GA4GH) aims to accelerate biomedical advances by enabling the responsible sharing of clinical and genomic data through both harmonized data aggregation and federated...
4.
Mallick H, Rahnavard A, McIver L, Ma S, Zhang Y, Nguyen L, et al.
PLoS Comput Biol
. 2021 Nov;
17(11):e1009442.
PMID: 34784344
It is challenging to associate features such as human health outcomes, diet, environmental conditions, or other metadata to microbial community measurements, due in part to their quantitative properties. Microbiome multi-omics...
5.
Jardine L, Webb S, Goh I, Quiroga Londono M, Reynolds G, Mather M, et al.
Nature
. 2021 Sep;
598(7880):327-331.
PMID: 34588693
Haematopoiesis in the bone marrow (BM) maintains blood and immune cell production throughout postnatal life. Haematopoiesis first emerges in human BM at 11-12 weeks after conception, yet almost nothing is...
6.
Ma S, Ren B, Mallick H, Moon Y, Schwager E, Maharjan S, et al.
PLoS Comput Biol
. 2021 Sep;
17(9):e1008913.
PMID: 34516542
Many methods have been developed for statistical analysis of microbial community profiles, but due to the complex nature of typical microbiome measurements (e.g. sparsity, zero-inflation, non-independence, and compositionality) and of...
7.
Delorey T, Ziegler C, Heimberg G, Normand R, Yang Y, Segerstolpe A, et al.
Nature
. 2021 Apr;
595(7865):107-113.
PMID: 33915569
COVID-19, which is caused by SARS-CoV-2, can result in acute respiratory distress syndrome and multiple organ failure, but little is known about its pathophysiology. Here we generated single-cell atlases of...
8.
Delorey T, Ziegler C, Heimberg G, Normand R, Yang Y, Segerstolpe A, et al.
bioRxiv
. 2021 Mar;
PMID: 33655247
The SARS-CoV-2 pandemic has caused over 1 million deaths globally, mostly due to acute lung injury and acute respiratory distress syndrome, or direct complications resulting in multiple-organ failures. Little is...
9.
Slyper M, Porter C, Ashenberg O, Waldman J, Drokhlyansky E, Wakiro I, et al.
Nat Med
. 2020 Jun;
26(8):1307.
PMID: 32587393
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
10.
Slyper M, Porter C, Ashenberg O, Waldman J, Drokhlyansky E, Wakiro I, et al.
Nat Med
. 2020 May;
26(5):792-802.
PMID: 32405060
Single-cell genomics is essential to chart tumor ecosystems. Although single-cell RNA-Seq (scRNA-Seq) profiles RNA from cells dissociated from fresh tumors, single-nucleus RNA-Seq (snRNA-Seq) is needed to profile frozen or hard-to-dissociate...