Curtis Huttenhower
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Explore the profile of Curtis Huttenhower including associated specialties, affiliations and a list of published articles.
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308
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62357
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Recent Articles
1.
Britton G, Mogno I, Chen-Liaw A, Plitt T, Helmus D, Bongers G, et al.
bioRxiv
. 2025 Jan;
PMID: 39868147
We examine disease-specific and cross-disease functions of the human gut microbiome by colonizing germ-free mice, at risk for inflammatory arthritis, colitis, or neuroinflammation, with over 100 human fecal microbiomes from...
2.
Ghazi A, Thompson K, Bhosle A, Mei Z, Yan Y, Wang F, et al.
bioRxiv
. 2025 Jan;
PMID: 39829854
Genetic and genomic variation among microbial strains can dramatically influence their phenotypes and environmental impact, including on human health. However, inferential methods for quantifying these differences have been lacking. Strain-level...
3.
Fahur Bottino G, Bonham K, Patel F, McCann S, Zieff M, Naspolini N, et al.
Nat Commun
. 2025 Jan;
16(1):660.
PMID: 39809768
Characterizing the dynamics of microbial community succession in the infant gut microbiome is crucial for understanding child health and development, but no normative model currently exists. Here, we estimate child...
4.
Nakatsu G, Ko D, Michaud M, Franzosa E, Morgan X, Huttenhower C, et al.
mBio
. 2025 Jan;
16(2):e0373224.
PMID: 39807864
is a bacterium associated with colorectal cancer (CRC) tumorigenesis, progression, and metastasis. Fap2 is a fusobacteria-specific outer membrane galactose-binding lectin that mediates adherence to and invasion of CRC tumors. Advances...
5.
Richards-Corke K, Jiang Y, Yeliseyev V, Zhang Y, Franzosa E, Wang Z, et al.
ACS Chem Biol
. 2025 Jan;
20(1):48-55.
PMID: 39778875
Hyperammonemia is characterized by the accumulation of ammonia within the bloodstream upon liver injury. Left untreated, hyperammonemia contributes to conditions such as hepatic encephalopathy that have high rates of patient...
6.
Hsu T, Nzabarushimana E, Wong D, Luo C, Beiko R, Langille M, et al.
Nat Microbiol
. 2025 Jan;
10(1):94-111.
PMID: 39747694
Lateral gene transfer (LGT), also known as horizontal gene transfer, facilitates genomic diversification in microbial populations. While previous work has surveyed LGT in human-associated microbial isolate genomes, the landscape of...
7.
Bhosle A, Jackson M, Walsh A, Franzosa E, Badri D, Huttenhower C
mSystems
. 2024 Dec;
10(1):e0045224.
PMID: 39714168
Importance: Consumption of dietary fiber changes the composition of the gut microbiome and, to a larger extent, the associated metabolites. Production of health-relevant metabolites such as short-chain fatty acids from...
8.
Nickols W, Kuntz T, Shen J, Maharjan S, Mallick H, Franzosa E, et al.
bioRxiv
. 2024 Dec;
PMID: 39713460
A key question in microbial community analysis is determining which microbial features are associated with community properties such as environmental or health phenotypes. This statistical task is impeded by characteristics...
9.
Nickols W, McIver L, Walsh A, Zhang Y, Nearing J, Asnicar F, et al.
bioRxiv
. 2024 Nov;
PMID: 39574575
Non-human-associated microbial communities play important biological roles, but they remain less understood than human-associated communities. Here, we assess the impact of key environmental sample properties on a variety of state-of-the-art...
10.
Manghi P, Bhosle A, Wang K, Marconi R, Selma-Royo M, Ricci L, et al.
Nat Microbiol
. 2024 Nov;
9(12):3120-3134.
PMID: 39558133
Although diet is a substantial determinant of the human gut microbiome, the interplay between specific foods and microbial community structure remains poorly understood. Coffee is a habitually consumed beverage with...