Timothy J Strovas
Overview
Explore the profile of Timothy J Strovas including associated specialties, affiliations and a list of published articles.
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13
Citations
311
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0
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Recent Articles
1.
McMillan P, Strovas T, Baum M, Mitchell B, Eck R, Hendricks N, et al.
Acta Neuropathol Commun
. 2021 Jun;
9(1):117.
PMID: 34187600
Several conserved nuclear RNA binding proteins (sut-1, sut-2, and parn-2) control tau aggregation and toxicity in C. elegans, mice, and human cells. MSUT2 protein normally resides in nuclear speckles, membraneless...
2.
Kow R, Strovas T, McMillan P, Jacobi A, Behlke M, Saxton A, et al.
Neurobiol Dis
. 2020 Nov;
147:105148.
PMID: 33184027
Aging drives pathological accumulation of proteins such as tau, causing neurodegenerative dementia disorders like Alzheimer's disease. Previously we showed loss of function mutations in the gene encoding the poly(A) RNA...
3.
Baker J, Uhrich R, Strovas T, Saxton A, Kraemer B
SLAS Discov
. 2020 Sep;
26(3):400-409.
PMID: 32981422
Tauopathies are neurological disorders characterized by intracellular tau deposits forming neurofibrillary tangles, neuropil threads, or other disease-specific aggregates composed of the protein tau. Tauopathy disorders include frontotemporal lobar degeneration, corticobasal...
4.
Targeting Pathological Tau by Small Molecule Inhibition of the Poly(A):MSUT2 RNA-Protein Interaction
Baker J, Uhrich R, Strovas T, Saxton A, Kraemer B
ACS Chem Neurosci
. 2020 Jun;
11(15):2277-2285.
PMID: 32589834
Neurofibrillary tangles composed of aberrantly aggregating tau protein are a hallmark of Alzheimer's disease and related dementia disorders. Recent work has shown that mammalian suppressor of tauopathy 2 (MSUT2), also...
5.
Benbow S, Strovas T, Darvas M, Saxton A, Kraemer B
Hum Mol Genet
. 2020 Jan;
29(3):495-505.
PMID: 31943011
Aggregates of Aβ peptide and the microtubule-associated protein tau are key molecular hallmarks of Alzheimer's disease (AD). However, the interaction between these two pathologies and the mechanisms underlying disease progression...
6.
Wheeler J, McMillan P, Strovas T, Liachko N, Amlie-Wolf A, Kow R, et al.
Sci Transl Med
. 2019 Dec;
11(523).
PMID: 31852801
Brain lesions composed of pathological tau help to drive neurodegeneration in Alzheimer's disease (AD) and related tauopathies. Here, we identified the mammalian suppressor of tauopathy 2 () gene as a...
7.
Liachko N, Saxton A, McMillan P, Strovas T, Keene C, Bird T, et al.
PLoS Genet
. 2019 Dec;
15(12):e1008526.
PMID: 31834878
Pathological phosphorylated TDP-43 protein (pTDP) deposition drives neurodegeneration in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD-TDP). However, the cellular and genetic mechanisms at work in pathological TDP-43 toxicity...
8.
Waldherr S, Strovas T, Vadset T, Liachko N, Kraemer B
Nat Commun
. 2019 Oct;
10(1):4443.
PMID: 31570707
To endure over the organismal lifespan, neurons utilize multiple strategies to achieve protein homeostasis (proteostasis). Some homeostatic mechanisms act in a subcellular compartment-specific manner, but others exhibit trans-compartmental mechanisms of...
9.
Taylor L, McMillan P, Liachko N, Strovas T, Ghetti B, Bird T, et al.
Mol Neurodegener
. 2018 Feb;
13(1):7.
PMID: 29409526
Background: Progressive neuron loss in the frontal and temporal lobes of the cerebral cortex typifies frontotemporal lobar degeneration (FTLD). FTLD sub types are classified on the basis of neuronal aggregated...
10.
Liachko N, Saxton A, McMillan P, Strovas T, Currey H, Taylor L, et al.
Acta Neuropathol
. 2016 Jul;
132(4):545-61.
PMID: 27473149
Detergent insoluble inclusions of TDP-43 protein are hallmarks of the neuropathology in over 90 % of amyotrophic lateral sclerosis (ALS) cases and approximately half of frontotemporal dementia (FTLD-TDP) cases. In...