Brian C Kraemer
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Explore the profile of Brian C Kraemer including associated specialties, affiliations and a list of published articles.
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59
Citations
1940
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Recent Articles
1.
Eck R, Valdmanis P, Liachko N, Kraemer B
Mol Brain
. 2025 Jan;
18(1):1.
PMID: 39810199
Recent research has highlighted widespread dysregulation of alternative polyadenylation in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP). Here, we identify significant disruptions to 3` UTR...
2.
Riordan R, Saxton A, Han M, McMillan P, Kow R, Liachko N, et al.
Alzheimers Dement
. 2024 Dec;
21(2):e14468.
PMID: 39711302
Introduction: Genetic variation in the lysosomal and transmembrane protein 106B (TMEM106B) modifies risk for several neurodegenerative disorders, especially frontotemporal lobar degeneration (FTLD). The C-terminal (CT) domain of TMEM106B occurs as...
3.
Stanley T, Otero E, Knight A, Saxton A, Ding X, Borgen M, et al.
Dis Model Mech
. 2024 Oct;
17(9).
PMID: 39352120
Alzheimer's disease is associated with the misfolding and aggregation of two distinct proteins, beta-amyloid and tau. Previously, it has been shown that activation of the cytoprotective heat shock response (HSR)...
4.
Waldherr S, Han M, Saxton A, Vadset T, McMillan P, Wheeler J, et al.
Commun Biol
. 2024 Jul;
7(1):903.
PMID: 39060347
Pathological tau disrupts protein homeostasis (proteostasis) within neurons in Alzheimer's disease (AD) and related disorders. We previously showed constitutive activation of the endoplasmic reticulum unfolded protein response (UPR) transcription factor...
5.
Riordan R, Saxton A, McMillan P, Kow R, Liachko N, Kraemer B
bioRxiv
. 2024 Jun;
PMID: 38915598
Genetic variation in the lysosomal and transmembrane protein 106B (TMEM106B) modifies risk for a diverse range of neurodegenerative disorders, especially frontotemporal lobar degeneration (FTLD) with progranulin (PGRN) haplo-insufficiency, although the...
6.
Han M, Saxton A, Currey H, Waldherr S, Liachko N, Kraemer B
Dis Model Mech
. 2024 Mar;
17(3).
PMID: 38469687
Protein homeostasis is perturbed in aging-related neurodegenerative diseases called tauopathies, which are pathologically characterized by aggregation of the microtubule-associated protein tau (encoded by the human MAPT gene). Transgenic Caenorhabditis elegans...
7.
Jadhav V, Stair J, Eck R, Smukowski S, Currey H, Toscano L, et al.
Neurobiol Dis
. 2024 Feb;
193:106441.
PMID: 38378122
Alzheimer's disease (AD), the most common aging-associated neurodegenerative dementia disorder, is defined by the presence of amyloid beta (Aβ) and tau aggregates in the brain. However, more than half of...
8.
Logsdon A, Foresi B, Hu S, Quah E, Meuret C, Le J, et al.
J Neurochem
. 2024 Feb;
168(9):1923-1936.
PMID: 38317026
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by clinical symptoms of memory and cognitive deficiencies. Postmortem evaluation of AD brain tissue shows proteinopathy that closely associate with the...
9.
Eck R, Stair J, Kraemer B, Liachko N
Front Neurosci
. 2024 Jan;
17:1300705.
PMID: 38239833
The nematode are a powerful model system to study human disease, with numerous experimental advantages including significant genetic and cellular homology to vertebrate animals, a short lifespan, and tractable behavioral,...
10.
Currey H, Kraemer B, Liachko N
MicroPubl Biol
. 2023 Aug;
2023.
PMID: 37602280
Expression of human tau in neurons causes progressive, age-associated loss of motor coordination, selective neurodegeneration, and shortened lifespan. Loss of function (LOF) mutations in the conserved gene protects against progressive...