Tim Hui-Ming Huang
Overview
Explore the profile of Tim Hui-Ming Huang including associated specialties, affiliations and a list of published articles.
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65
Citations
2439
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Recent Articles
1.
Chou C, Hung C, Hsiang-Ling Chiu C, Tan X, Chen M, Chen C, et al.
Nat Commun
. 2023 Oct;
14(1):6569.
PMID: 37848444
While macrophage phagocytosis is an immune defense mechanism against invading cellular organisms, cancer cells expressing the CD47 ligand send forward signals to repel this engulfment. Here we report that the...
2.
Chen L, Zhang Z, Han Q, Maity B, Rodrigues L, Zboril E, et al.
Mol Cell
. 2023 Sep;
83(19):3438-3456.e12.
PMID: 37738977
Transcription factors (TFs) activate enhancers to drive cell-specific gene programs in response to signals, but our understanding of enhancer assembly during signaling events is incomplete. Here, we show that androgen...
3.
Burleson M, Deng J, Qin T, Duong T, Yan Y, Gu X, et al.
Mol Cancer Res
. 2021 Oct;
20(1):62-76.
PMID: 34610962
Although the Sonic hedgehog (SHH) signaling pathway has been implicated in promoting malignant phenotypes of prostate cancer, details on how it is activated and exerts its oncogenic role during prostate...
4.
Chou C, Tan X, Hung C, Lieberman B, Chen M, Kusi M, et al.
Cancers (Basel)
. 2020 Sep;
12(9).
PMID: 32971831
The interplay between glycolysis and mitochondrial oxidative phosphorylation (OXPHOS) is central to maintain energy homeostasis. It remains to be determined whether there is a mechanism governing metabolic fluxes based on...
5.
Bi M, Zhang Z, Jiang Y, Xue P, Wang H, Lai Z, et al.
Nat Cell Biol
. 2020 May;
22(6):701-715.
PMID: 32424275
Acquired therapy resistance is a major problem for anticancer treatment, yet the underlying molecular mechanisms remain unclear. Using an established breast cancer cellular model, we show that endocrine resistance is...
6.
Waha A, Rodrigues F, Waha A, Meyer-Puttlitz B, Cavenee W, Huang T, et al.
Cancer Genomics Proteomics
. 2019 Aug;
1(3):209-214.
PMID: 31394655
Hypermethylation of CpG island is an epigenetic event prevalent in human gliomas. Here we employed a high-throughput microarray approach for a global search of DNA methylation to identify novel epigenetic...
7.
Zhu C, Li L, Zhang Z, Bi M, Wang H, Su W, et al.
Mol Cell
. 2019 Jul;
75(4):791-806.e8.
PMID: 31303470
YAP/TEAD are nuclear effectors of the Hippo pathway, regulating organ size and tumorigenesis largely through promoter-associated function. However, their function as enhancer regulators remains poorly understood. Through an in vivo...
8.
Panneerdoss S, Eedunuri V, Yadav P, Timilsina S, Rajamanickam S, Viswanadhapalli S, et al.
Sci Adv
. 2018 Oct;
4(10):eaar8263.
PMID: 30306128
The importance of RNA methylation in biological processes is an emerging focus of investigation. We report that altering mA levels by silencing either -adenosine methyltransferase METTL14 (methyltransferase-like 14) or demethylase...
9.
Hussain S, Huang S, Bedolla R, Rivas P, Basler J, Swanson G, et al.
Cancer Lett
. 2018 Jul;
433:232-241.
PMID: 30003927
Radiation therapy (XRT) is a standard treatment for prostate cancer (PCa). Although dose escalation increases local control, toxicity hampers further escalation. Broader improvement will be possible by the addition of...
10.
Zhang W, Chen J, Shan T, Aguilera-Barrantes I, Wang L, Huang T, et al.
Lab Invest
. 2018 Jun;
98(11):1397-1407.
PMID: 29955087
Endometrial cancer is the most common gynecological cancer in the United States. We wanted to identify epigenetic aberrations involving microRNAs (miRNAs), whose genes become hypermethylated in endometrial primary tumors. By...