Thuy-Ai Nguyen
Overview
Explore the profile of Thuy-Ai Nguyen including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
821
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0
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Recent Articles
1.
Shuptrine C, Chen Y, Miriyala J, Lenz K, Moffett D, Nguyen T, et al.
Cancer Res
. 2024 Feb;
84(10):1550-1559.
PMID: 38381555
Significance: Lipid nanoparticle-encapsulated mRNA can efficiently encode complex fusion proteins encompassing immune checkpoint blockers and costimulators that functionally oligomerize in vivo with extended pharmacokinetics and durable exposure to induce potent...
2.
Yoo K, Johannes K, Gonzalez L, Patel A, Shuptrine C, Opheim Z, et al.
J Immunol
. 2022 Jul;
209(3):510-525.
PMID: 35817517
Coinhibition of TIGIT (T cell immunoreceptor with Ig and ITIM domains) and PD-1/PD-L1 (PD-1/L1) may improve response rates compared with monotherapy PD-1/L1 blockade in checkpoint naive non-small cell lung cancer...
3.
Menendez D, Nguyen T, Snipe J, Resnick M
Mol Cancer Res
. 2017 Feb;
15(6):735-743.
PMID: 28232385
The APOBEC3 (A3) family of proteins are DNA cytidine deaminases that act as sentinels in the innate immune response against retroviral infections and are responsive to IFN. Recently, a few...
4.
Lowe J, Nguyen T, Grimm S, Gabor K, Peddada S, Li L, et al.
Cell Death Differ
. 2016 Nov;
24(1):181-191.
PMID: 27834950
Tumor necrosis factor-α-induced protein 8 (TNFAIP8) is a stress-response gene that has been associated with cancer, but no studies have differentiated among or defined the regulation or function of any...
5.
Nguyen T, Menendez D, Resnick M, Anderson C
Hum Mutat
. 2014 Jan;
35(6):738-55.
PMID: 24395704
The wild-type (WT) human p53 (TP53) tumor suppressor can be posttranslationally modified at over 60 of its 393 residues. These modifications contribute to changes in TP53 stability and in its...
6.
Menendez D, Nguyen T, Freudenberg J, Mathew V, Anderson C, Jothi R, et al.
Nucleic Acids Res
. 2013 Jun;
41(15):7286-301.
PMID: 23775793
The effects of diverse stresses on promoter selectivity and transcription regulation by the tumor suppressor p53 are poorly understood. We have taken a comprehensive approach to characterizing the human p53...
7.
Parikh N, Shuck R, Nguyen T, Herron A, Donehower L
Mol Cancer Res
. 2012 Apr;
10(6):845-55.
PMID: 22532587
Mutation of K-Ras is a frequent oncogenic event in human cancers, particularly cancers of lungs, pancreas, and colon. It remains unclear why some tissues are more susceptible to Ras-induced transformation...
8.
Moon S, Nguyen T, Darlington Y, Lu X, Donehower L
Cell Cycle
. 2010 May;
9(11):2092-6.
PMID: 20495376
DNA double strand breaks are a particularly toxic form of DNA damage and the mammalian cell has evolved an intricate set of responses to repair this type of DNA lesion....
9.
Nguyen T, Slattery S, Moon S, Darlington Y, Lu X, Donehower L
DNA Repair (Amst)
. 2010 May;
9(7):813-23.
PMID: 20451471
Nucleotide excision repair (NER) is the only mechanism in humans to repair UV-induced DNA lesions such as pyrimidine (6-4) pyrimidone photoproducts and cyclobutane pyrimidine dimers (CPDs). In response to UV...
10.
Moon S, Lin L, Zhang X, Nguyen T, Darlington Y, Waldman A, et al.
J Biol Chem
. 2010 Feb;
285(17):12935-47.
PMID: 20118229
In response to DNA double strand breaks, the histone variant H2AX at the break site is phosphorylated at serine 139 by DNA damage sensor kinases such as ataxia telangiectasia-mutated, forming...