Taylor H Schreiber
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Explore the profile of Taylor H Schreiber including associated specialties, affiliations and a list of published articles.
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30
Citations
1129
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Recent Articles
1.
Johnson M, Hong D, Brana I, Schoffski P, Galvao V, Rangwala F, et al.
Invest New Drugs
. 2025 Mar;
PMID: 40042547
SL-279252 is a bifunctional hexameric fusion protein adjoining the extracellular domains of PD-1 and OX40L via an inert IgG4 derived Fc domain. A Phase 1 dose escalation study was conducted...
2.
Shuptrine C, Chen Y, Miriyala J, Lenz K, Moffett D, Nguyen T, et al.
Cancer Res
. 2024 Feb;
84(10):1550-1559.
PMID: 38381555
Significance: Lipid nanoparticle-encapsulated mRNA can efficiently encode complex fusion proteins encompassing immune checkpoint blockers and costimulators that functionally oligomerize in vivo with extended pharmacokinetics and durable exposure to induce potent...
3.
Memon D, Schoenfeld A, Ye D, Fromm G, Rizvi H, Zhang X, et al.
Cancer Cell
. 2024 Jan;
42(2):209-224.e9.
PMID: 38215748
Although immunotherapy with PD-(L)1 blockade is routine for lung cancer, little is known about acquired resistance. Among 1,201 patients with non-small cell lung cancer (NSCLC) treated with PD-(L)1 blockade, acquired...
4.
Fromm G, de Silva S, Schreiber T
Front Immunol
. 2023 Oct;
14:1236332.
PMID: 37795079
The extracellular domain of tumor necrosis factor receptors (TNFR) generally require assembly into a homotrimeric quaternary structure as a prerequisite for initiation of signaling via the cytoplasmic domains. TNF receptor...
5.
Shuptrine C, Perez V, Selitsky S, Schreiber T, Fromm G
Eur J Cancer
. 2023 May;
187:147-160.
PMID: 37167762
Despite over a decade of clinical trials combining inhibition of emerging checkpoints with a PD-1/L1 inhibitor backbone, meaningful survival benefits have not been shown in PD-1/L1 inhibitor resistant or refractory...
6.
Lai A, Patel A, Brewer F, Evans K, Johannes K, Gonzalez L, et al.
J Immunol
. 2022 Sep;
209(8):1475-1480.
PMID: 36096643
Vγ9Vδ2 T cell-targeted immunotherapy is of interest to harness its MHC-independent cytotoxic potential against a variety of cancers. Recent studies have identified heterodimeric butyrophilin (BTN) 2A1 and BTN3A1 as the...
7.
Yoo K, Johannes K, Gonzalez L, Patel A, Shuptrine C, Opheim Z, et al.
J Immunol
. 2022 Jul;
209(3):510-525.
PMID: 35817517
Coinhibition of TIGIT (T cell immunoreceptor with Ig and ITIM domains) and PD-1/PD-L1 (PD-1/L1) may improve response rates compared with monotherapy PD-1/L1 blockade in checkpoint naive non-small cell lung cancer...
8.
de Silva S, Fromm G, Shuptrine C, Johannes K, Patel A, Yoo K, et al.
Cancer Immunol Res
. 2019 Dec;
8(2):230-245.
PMID: 31852716
Disrupting the binding of CD47 to SIRPα has emerged as a promising immunotherapeutic strategy for advanced cancers by potentiating antibody-dependent cellular phagocytosis (ADCP) of targeted antibodies. Preclinically, CD47/SIRPα blockade induces...
9.
Fromm G, de Silva S, Johannes K, Patel A, Hornblower J, Schreiber T
J Immunother Cancer
. 2018 Dec;
6(1):149.
PMID: 30563566
Simultaneous blockade of immune checkpoint molecules and co-stimulation of the TNF receptor superfamily (TNFRSF) is predicted to improve overall survival in human cancer. TNFRSF co-stimulation depends upon coordinated antigen recognition...
10.
Triplett T, Garrison K, Marshall N, Donkor M, Blazeck J, Lamb C, et al.
Nat Biotechnol
. 2018 Jul;
36(8):758-764.
PMID: 30010674
Increased tryptophan (Trp) catabolism in the tumor microenvironment (TME) can mediate immune suppression by upregulation of interferon (IFN)-γ-inducible indoleamine 2,3-dioxygenase (IDO1) and/or ectopic expression of the predominantly liver-restricted enzyme tryptophan...