Thuy-Ai Nguyen
Overview
Explore the profile of Thuy-Ai Nguyen including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
821
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0
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Recent Articles
11.
Lu X, Nguyen T, Zhang X, Donehower L
Cell Cycle
. 2008 Mar;
7(2):164-8.
PMID: 18333294
The p53 tumor suppressor is essential in maintaining genomic integrity in response to cellular stresses. In response to DNA damage, p53 is activated and stabilized largely through post-translational modifications, including...
12.
Lu X, Nguyen T, Moon S, Darlington Y, Sommer M, Donehower L
Cancer Metastasis Rev
. 2008 Feb;
27(2):123-35.
PMID: 18265945
The Wild-type p53-induced phosphatase 1, Wip1 (or PPM1D), is unusual in that it is a serine/threonine phosphatase with oncogenic activity. A member of the type 2C phosphatases (PP2Cdelta), Wip1 has...
13.
Lu X, Ma O, Nguyen T, Jones S, Oren M, Donehower L
Cancer Cell
. 2007 Oct;
12(4):342-54.
PMID: 17936559
The tumor suppressor p53 is a transcription factor that responds to cellular stresses by initiating cell cycle arrest or apoptosis. One transcriptional target of p53 is Mdm2, an E3 ubiquitin...
14.
Castellino R, De Bortoli M, Lu X, Moon S, Nguyen T, Shepard M, et al.
J Neurooncol
. 2007 Oct;
86(3):245-56.
PMID: 17932621
Medulloblastoma is the most common malignant brain tumor of childhood. Despite numerous advances, clinical challenges range from recurrent and progressive disease to long-term toxicities in survivors. The lack of more...
15.
Nannenga B, Lu X, Dumble M, van Maanen M, Nguyen T, Sutton R, et al.
Mol Carcinog
. 2006 May;
45(8):594-604.
PMID: 16652371
The p53-induced serine/threonine phosphatase, protein phosphatase 1D magnesium-dependent, delta isoform (PPM1D) (or wild-type p53-induced phosphatase 1 (Wip1)), exhibits oncogenic activity in vitro and in vivo. It behaves as an oncogene...
16.
Lu X, Nguyen T, Donehower L
Cell Cycle
. 2005 Jun;
4(8):1060-4.
PMID: 15970689
The eukaryotic cell has evolved a sophisticated set of cell signaling pathways that respond to DNA damage and efficiently repair that damage, protecting the cell from deleterious mutations, genomic instability,...
17.
Lu X, Nguyen T, Appella E, Donehower L
Cell Cycle
. 2004 Nov;
3(11):1363-6.
PMID: 15539943
The p53 protein plays a central role in the integration of cellular stress responses. If the cell incurs DNA damage, p53-induced cell cycle arrest is accompanied by p53-facilitated DNA repair....
18.
Ota T, Nguyen T, Huang E, Detrich 3rd H, Amemiya C
J Exp Zool B Mol Dev Evol
. 2003 Jan;
295(1):45-58.
PMID: 12548542
The cooling of the Southern Ocean to the freezing point of seawater (-1.9 degrees C) over the past 25 million years played a dominant selective role in the evolution of...