Thomas Sandmann
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Explore the profile of Thomas Sandmann including associated specialties, affiliations and a list of published articles.
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37
Citations
1918
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Recent Articles
1.
Khoury N, Pizzo M, Discenza C, Joy D, Tatarakis D, Todorov M, et al.
Nat Commun
. 2025 Feb;
16(1):1822.
PMID: 39979268
Blood brain barrier-crossing molecules targeting transferrin receptor (TfR) and CD98 heavy chain (CD98hc) are widely reported to promote enhanced brain delivery of therapeutics. Here, we provide a comprehensive and unbiased...
2.
Guo J, Braun D, Fitzgerald G, Hsieh Y, Rouge L, Litvinchuk A, et al.
Cell
. 2024 Nov;
188(1):187-206.e26.
PMID: 39532095
While apolipoprotein E (APOE) is the strongest genetic modifier for late-onset Alzheimer's disease (LOAD), the molecular mechanisms underlying isoform-dependent risk and the relevance of ApoE-associated lipids remain elusive. Here, we...
3.
Yulyaningsih E, Suh J, Fanok M, Chau R, Solanoy H, Takahashi R, et al.
Elife
. 2024 Sep;
12.
PMID: 39287504
The integrated stress response (ISR) is a conserved pathway in eukaryotic cells that is activated in response to multiple sources of cellular stress. Although acute activation of this pathway restores...
4.
Barker S, Thayer M, Kim C, Tatarakis D, Simon M, Dial R, et al.
Sci Transl Med
. 2024 Aug;
16(760):eadi2245.
PMID: 39141703
Antisense oligonucleotides (ASOs) are promising therapeutics for treating various neurological disorders. However, ASOs are unable to readily cross the mammalian blood-brain barrier (BBB) and therefore need to be delivered intrathecally...
5.
Reich M, Simon M, Polke B, Paris I, Werner G, Schrader C, et al.
Sci Transl Med
. 2024 Jun;
16(750):eadj7308.
PMID: 38838131
Progranulin (PGRN) haploinsufficiency is a major risk factor for frontotemporal lobar degeneration with TAR DNA-binding protein 43 (TDP-43) pathology (FTLD-). Multiple therapeutic strategies are in clinical development to restore PGRN...
6.
Andrews S, Kukkle P, Menon R, Geetha T, Goyal V, Kandadai R, et al.
Mov Disord
. 2023 Nov;
39(2):339-349.
PMID: 38014556
Background: Recent studies have advanced our understanding of the genetic drivers of Parkinson's disease (PD). Rare variants in more than 20 genes are considered causal for PD, and the latest...
7.
Xia D, Lianoglou S, Sandmann T, Calvert M, Suh J, Thomsen E, et al.
Mol Neurodegener
. 2022 Jun;
17(1):41.
PMID: 35690868
Background: Genetic mutations underlying familial Alzheimer's disease (AD) were identified decades ago, but the field is still in search of transformative therapies for patients. While mouse models based on overexpression...
8.
Daemen A, Udyavar A, Sandmann T, Li C, Bosch L, OGorman W, et al.
PLoS One
. 2021 Dec;
16(12):e0262198.
PMID: 34972191
Background: Colorectal cancer (CRC) is a leading cause of cancer-related deaths, with a 5% 5-year survival rate for metastatic disease, yet with limited therapeutic advancements due to insufficient understanding of...
9.
Andreone B, Przybyla L, Llapashtica C, Rana A, Davis S, van Lengerich B, et al.
Nat Neurosci
. 2020 Jun;
23(8):927-938.
PMID: 32514138
Human genetic data indicate that microglial dysfunction contributes to the pathology of Alzheimer's disease (AD), exemplified by the identification of coding variants in triggering receptor expressed on myeloid cells 2...
10.
Ullman J, Arguello A, Getz J, Bhalla A, Mahon C, Wang J, et al.
Sci Transl Med
. 2020 May;
12(545).
PMID: 32461331
Most lysosomal storage diseases (LSDs) involve progressive central nervous system (CNS) impairment, resulting from deficiency of a lysosomal enzyme. Treatment of neuronopathic LSDs remains a considerable challenge, as approved intravenously...